ID 143G_SHEEP STANDARD; PRT; 158 AA. AC P68253; P29359; DT 01-DEC-1992 (Rel. 24, Created) DT 25-OCT-2004 (Rel. 45, Last sequence update) DT 25-OCT-2004 (Rel. 45, Last annotation update) DE 14-3-3 protein gamma (Protein kinase C inhibitor protein-1) (KCIP-1) DE (Fragments). GN Name=YWHAG; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; OC Caprinae; Ovis. OX NCBI_TaxID=9940; RN [1] RP PROTEIN SEQUENCE. RC TISSUE=Brain; RX MEDLINE=92283271; PubMed=1317796; RA Toker A., Sellers L.A., Amess B., Patel Y., Harris A., Aitken A.; RT "Multiple isoforms of a protein kinase C inhibitor (KCIP-1/14-3-3) RT from sheep brain. Amino acid sequence of phosphorylated forms."; RL Eur. J. Biochem. 206:453-461(1992). CC -!- FUNCTION: Activates tyrosine and tryptophan hydroxylases in the CC presence of Ca(2+)/calmodulin-dependent protein kinase II, and CC strongly activates protein kinase C. Is probably a multifunctional CC regulator of the cell signaling processes mediated by both CC kinases. CC -!- SUBUNIT: Homodimer. Interacts with RAF1 (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasmic. CC -!- TISSUE SPECIFICITY: 14-3-3 proteins are localized in neurons, and CC are axonally transported to the nerve terminals. They may be also CC present, at lower levels, in various other eukaryotic tissues. CC -!- PTM: N-terminus residue is acetylated (By similarity). CC -!- SIMILARITY: Belongs to the 14-3-3 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR HSSP; P93343; 1O9E. DR InterPro; IPR000308; 14-3-3. DR SMART; SM00101; 14_3_3; 1. DR PROSITE; PS00796; 1433_1; 1. DR PROSITE; PS00797; 1433_2; 1. KW Acetylation; Direct protein sequencing; Multigene family; KW Phosphorylation. FT NON_TER 1 1 FT NON_CONS 48 49 FT NON_CONS 113 114 FT NON_TER 158 158 SQ SEQUENCE 158 AA; 18000 MW; 69EC73EBA23B7B6F CRC64; AAAMKNVTEL NEPLSNEERN LLSVAYKNVV GARRSSWRVI SSIEQKTSFY LKMKGDYYRY LAEVATGEKR ATVVESSEKA YSEAHEISKE HMQPTHPIRL GLALNYSVFY YEITAFDDAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DQQDDDGG //