ID HBG_ATEGE Reviewed; 147 AA. AC P68068; P06891; DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 22-FEB-2023, entry version 67. DE RecName: Full=Hemoglobin subunit gamma; DE AltName: Full=Gamma-globin; DE AltName: Full=Hemoglobin gamma chain; GN Name=HBG; OS Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Atelidae; OC Atelinae; Ateles. OX NCBI_TaxID=9509; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=2413451; DOI=10.1073/pnas.82.20.6985; RA Giebel L.B., van Santen V.L., Slightom J.L., Spritz R.A.; RT "Nucleotide sequence, evolution, and expression of the fetal globin gene of RT the spider monkey Ateles geoffroyi."; RL Proc. Natl. Acad. Sci. U.S.A. 82:6985-6989(1985). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=1908094; DOI=10.1073/pnas.88.16.7396; RA Fitch D.H., Bailey W.J., Tagle D.A., Goodman M., Sieu L., Slightom J.L.; RT "Duplication of the gamma-globin gene mediated by L1 long interspersed RT repetitive elements in an early ancestor of simian primates."; RL Proc. Natl. Acad. Sci. U.S.A. 88:7396-7400(1991). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=10222158; DOI=10.1006/mpev.1998.0574; RA Meireles C.M., Czelusniak J., Schneider M.P.C., Muniz J.A.P.C., RA Brigido M.C., Ferreira H.S., Goodman M.; RT "Molecular phylogeny of ateline new world monkeys (Platyrrhini, atelinae) RT based on gamma-globin gene sequences: evidence that Brachyteles is the RT sister group of Lagothrix."; RL Mol. Phylogenet. Evol. 12:10-30(1999). CC -!- FUNCTION: Gamma chains make up the fetal hemoglobin F, in combination CC with alpha chains. CC -!- SUBUNIT: Heterotetramer of two alpha chains and two gamma chains in CC fetal hemoglobin (Hb F). CC -!- TISSUE SPECIFICITY: Red blood cells. CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE- CC ProRule:PRU00238}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M36773; AAA36926.1; -; Genomic_DNA. DR EMBL; X53420; CAA37499.1; -; Genomic_DNA. DR EMBL; AF030092; AAB92226.1; -; Genomic_DNA. DR PIR; S21892; HGMKS. DR AlphaFoldDB; P68068; -. DR SMR; P68068; -. DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW. DR GO; GO:0015670; P:carbon dioxide transport; IEA:UniProt. DR GO; GO:0010942; P:positive regulation of cell death; IEA:UniProt. DR CDD; cd08925; Hb-beta-like; 1. DR Gene3D; 1.10.490.10; Globins; 1. DR InterPro; IPR000971; Globin. DR InterPro; IPR009050; Globin-like_sf. DR InterPro; IPR012292; Globin/Proto. DR InterPro; IPR002337; Hemoglobin_b. DR PANTHER; PTHR11442; HEMOGLOBIN FAMILY MEMBER; 1. DR PANTHER; PTHR11442:SF52; HEMOGLOBIN SUBUNIT GAMMA-1; 1. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00814; BETAHAEM. DR SUPFAM; SSF46458; Globin-like; 1. DR PROSITE; PS01033; GLOBIN; 1. PE 2: Evidence at transcript level; KW Heme; Iron; Metal-binding; Oxygen transport; Transport. FT CHAIN 1..147 FT /note="Hemoglobin subunit gamma" FT /id="PRO_0000053237" FT BINDING 64 FT /ligand="heme b" FT /ligand_id="ChEBI:CHEBI:60344" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="distal binding residue" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238" FT BINDING 93 FT /ligand="heme b" FT /ligand_id="ChEBI:CHEBI:60344" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="proximal binding residue" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238" SQ SEQUENCE 147 AA; 15940 MW; 8DFA15C6D043FA17 CRC64; MSNFTAEDKA AITSLWGKVN VEDAGGETLG RLLVVYPWTQ RFFDSFGSLS SPSAIMGNPK VKAHGVKVLT SLGEAIKNLD DLKGTFGQLS ELHCDKLHVD PENFRLLGNV LVTVLAILHG KEFTPEVQAS WQKMVAGVAS ALASRYH //