ID PANE_STRPY STANDARD; PRT; 307 AA. AC P65666; Q9A0B3; DT 28-FEB-2003 (Rel. 41, Created) DT 25-OCT-2004 (Rel. 45, Last sequence update) DT 10-MAY-2005 (Rel. 47, Last annotation update) DE Putative 2-dehydropantoate 2-reductase (EC 1.1.1.169) (Ketopantoate DE reductase) (KPA reductase) (KPR). GN Name=apbA; OrderedLocusNames=SPy0852; OS Streptococcus pyogenes. OC Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=1314; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SF370 / ATCC 700294 / Serotype M1; RX MEDLINE=21192684; PubMed=11296296; DOI=10.1073/pnas.071559398; RA Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., RA Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., RA Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., RA Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E.; RT "Complete genome sequence of an M1 strain of Streptococcus pyogenes."; RL Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001). CC -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate CC into pantoic acid (By similarity). CC -!- CATALYTIC ACTIVITY: (R)-pantoate + NADP(+) = 2-dehydropantoate + CC NADPH. CC -!- PATHWAY: Cofactor biosynthesis; pantothenate biosynthesis; CC pantoate from 3-methyl-2-oxobutanoate: step 2. CC -!- SUBCELLULAR LOCATION: Cytoplasmic (Potential). CC -!- SIMILARITY: Belongs to the ketopantoate reductase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE006535; AAK33780.1; -; Genomic_DNA. DR InterPro; IPR003710; ApbA. DR Pfam; PF02558; ApbA; 1. DR TIGRFAMs; TIGR00745; apbA_panE; 1. KW Complete proteome; NADP; Oxidoreductase; Pantothenate biosynthesis. FT NP_BIND 7 12 NADP (Potential). FT ACT_SITE 184 184 By similarity. FT ACT_SITE 268 268 By similarity. SQ SEQUENCE 307 AA; 33829 MW; 46F6298D3BD958E6 CRC64; MLVYIAGSGA MGCRFGYQIS KTNNDVILLD NWEDHINAIK ENGLVVTGDV EETVKLPIMK PTEATQEADL IILFTKAMQL PQMLQDIKGI IGKETKVLCL LNGLGHEDVI RQYIPEHNIL MGVTVWTAGL EGPGRAHLQG VGALNLQSMD PSNQEAGHQV ADLLNEANLN ATYDENVVPN IWRKACVNGT MNSTCALLDC TIGELFASED GLKMVKEIIH EFVIVGQAEG VELNEEEITQ YVMDTSVKAA HHYPSMHQDL VQNHRLTEID FINGAVNTKG EKLGINTPYC RMITELVHAK EAVLNIQ //