ID   SMD3_HUMAN              Reviewed;         126 AA.
AC   P62318; P43331;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   06-FEB-2007, entry version 34.
DE   Small nuclear ribonucleoprotein Sm D3 (snRNP core protein D3) (Sm-D3).
GN   Name=SNRPD3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   MEDLINE=95083692; PubMed=7527560;
RA   Lehmeier T., Raker V., Hermann H., Luehrmann R.;
RT   "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear
RT   ribonucleoproteins: evidence for a direct D1-D2 interaction.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:12317-12321(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA   Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA   Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA   Beare D.M., Dunham I.;
RT   "A genome annotation-driven approach to cloning the human ORFeome.";
RL   Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   METHYLATION.
RX   MEDLINE=21614655; PubMed=11747828; DOI=10.1016/S0960-9822(01)00592-9;
RA   Meister G., Eggert C., Buehler D., Brahms H., Kambach C., Fischer U.;
RT   "Methylation of Sm proteins by a complex containing PRMT5 and the
RT   putative U snRNP assembly factor pICln.";
RL   Curr. Biol. 11:1990-1994(2001).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE
RP   SPICEOSOMAL C COMPLEX.
RX   PubMed=11991638; DOI=10.1017/S1355838202021088;
RA   Jurica M.S., Licklider L.J., Gygi S.R., Grigorieff N., Moore M.J.;
RT   "Purification and characterization of native spliceosomes suitable for
RT   three-dimensional structural analysis.";
RL   RNA 8:426-439(2002).
RN   [6]
RP   METHYLATION [LARGE SCALE ANALYSIS] AT ARG-97, AND MASS SPECTROMETRY.
RX   PubMed=15782174; DOI=10.1038/nmeth715;
RA   Ong S.E., Mittler G., Mann M.;
RT   "Identifying and quantifying in vivo methylation sites by heavy methyl
RT   SILAC.";
RL   Nat. Methods 1:119-126(2004).
RN   [7]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 4-75 IN COMPLEX WITH SNRPB.
RX   MEDLINE=99148270; PubMed=10025403; DOI=10.1016/S0092-8674(00)80550-4;
RA   Kambach C., Walke S., Young R., Avis J.M., de la Fortelle E.,
RA   Raker V.A., Luehrmann R., Li J., Nagai K.;
RT   "Crystal structures of two Sm protein complexes and their implications
RT   for the assembly of the spliceosomal snRNPs.";
RL   Cell 96:375-387(1999).
CC   -!- SUBUNIT: Identified in the spliceosome C complex, at least
CC       composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23,
CC       DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1,
CC       GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK,
CC       HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1,
CC       PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B,
CC       PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2,
CC       SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2,
CC       SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2,
CC       SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8.
CC   -!- INTERACTION:
CC       P62310:LSM3; NbExp=1; IntAct=EBI-372789, EBI-348239;
CC       Q9UK45:LSM7; NbExp=1; IntAct=EBI-372789, EBI-348372;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- PTM: Methylated by SKB1.
CC   -!- PTM: Arg-97 is dimethylated, probably to asymmetric
CC       dimethylarginine.
CC   -!- DISEASE: In the autoimmune disease systemic lupus erythematosus,
CC       antinuclear antibodies are developed with Sm specificity.
CC   -!- SIMILARITY: Belongs to the snRNP core protein family.
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DR   EMBL; U15009; AAA57034.1; -; mRNA.
DR   EMBL; CR456583; CAG30469.1; -; mRNA.
DR   EMBL; BC000457; AAH00457.1; -; mRNA.
DR   EMBL; BC003150; AAH03150.1; -; mRNA.
DR   UniGene; Hs.356549; -.
DR   PDB; 1D3B; X-ray; A/C/E/G/I/K=1-75.
DR   IntAct; P62318; -.
DR   Ensembl; ENSG00000100028; Homo sapiens.
DR   HGNC; HGNC:11160; SNRPD3.
DR   HPA; HPA001170; -.
DR   MIM; 601062; gene.
DR   Reactome; REACT_1675.1; mRNA Processing.
DR   Reactome; REACT_1788.1; Transcription.
DR   Reactome; REACT_71.1; Gene Expression.
DR   ArrayExpress; P62318; -.
DR   RZPD-ProtExp; C0040; -.
DR   RZPD-ProtExp; F0465; -.
DR   RZPD-ProtExp; IOH12493; -.
DR   GO; GO:0030532; C:small nuclear ribonucleoprotein complex; TAS:ProtInc.
DR   GO; GO:0005681; C:spliceosome; TAS:ProtInc.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; TAS:ProtInc.
DR   InterPro; IPR006649; Euk_arc_LSM_core.
DR   InterPro; IPR010920; LSM_related_core.
DR   InterPro; IPR001163; LSM_snRNP_core.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
KW   3D-structure; Direct protein sequencing; Methylation; mRNA processing;
KW   mRNA splicing; Nuclear protein; Repeat; Ribonucleoprotein;
KW   Spliceosome; Systemic lupus erythematosus.
FT   CHAIN         1    126       Small nuclear ribonucleoprotein Sm D3.
FT                                /FTId=PRO_0000122214.
FT   REPEAT      110    111       1.
FT   REPEAT      112    113       2.
FT   REPEAT      114    115       3.
FT   REPEAT      116    117       4.
FT   REPEAT      118    119       5.
FT   REGION      110    119       5 X 2 AA tandem repeats of [RM]-G.
FT   COMPBIAS     84    126       Arg/Lys-rich (basic).
FT   MOD_RES      97     97       Omega-N-methylated arginine.
FT   HELIX         6     12
FT   TURN         13     15
FT   STRAND       16     22
FT   TURN         23     24
FT   STRAND       27     35
FT   TURN         37     38
FT   STRAND       41     49
FT   TURN         51     52
FT   STRAND       55     63
FT   HELIX        65     67
FT   STRAND       68     73
SQ   SEQUENCE   126 AA;  13916 MW;  59A6E78E860AA3E0 CRC64;
     MSIGVPIKVL HEAEGHIVTC ETNTGEVYRG KLIEAEDNMN CQMSNITVTY RDGRVAQLEQ
     VYIRGSKIRF LILPDMLKNA PMLKSMKNKN QGSGAGRGKA AILKAQVAAR GRGRGMGRGN
     IFQKRR
//