ID RUXF_HUMAN Reviewed; 86 AA. AC P62306; A2VCR2; Q15356; Q6IBQ1; Q6P4I0; DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 20-MAY-2008, entry version 39. DE Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) DE (SmF). GN Name=SNRPF; Synonyms=PBSCF; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Cervix carcinoma; RX MEDLINE=95262647; PubMed=7744013; RA Hermann H., Fabrizio P., Raker V.A., Foulaki K., Hornig H., Brahms H., RA Luehrmann R.; RT "snRNP Sm proteins share two evolutionarily conserved sequence motifs RT which are involved in Sm protein-protein interactions."; RL EMBO J. 14:2076-2088(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Colon; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE RP SPICEOSOMAL C COMPLEX. RX PubMed=11991638; DOI=10.1017/S1355838202021088; RA Jurica M.S., Licklider L.J., Gygi S.R., Grigorieff N., Moore M.J.; RT "Purification and characterization of native spliceosomes suitable for RT three-dimensional structural analysis."; RL RNA 8:426-439(2002). CC -!- FUNCTION: Associated with snRNP U1, U2, U4/U6 and U5. CC -!- SUBUNIT: Identified in the spliceosome C complex, at least CC composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, CC DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, CC GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, CC HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, CC PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, CC PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, CC SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, CC SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, CC SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. CC -!- INTERACTION: CC O95400:CD2BP2; NbExp=1; IntAct=EBI-356900, EBI-768015; CC Q9Y4Y9:LSM5; NbExp=1; IntAct=EBI-356900, EBI-373007; CC O15527:OGG1; NbExp=1; IntAct=EBI-356900, EBI-721675; CC P31930:UQCRC1; NbExp=1; IntAct=EBI-356900, EBI-1052596; CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family. SmF/LSm6 CC subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X85372; CAA59688.1; -; mRNA. DR EMBL; CR456751; CAG33032.1; -; mRNA. DR EMBL; BC002505; AAH02505.3; -; mRNA. DR EMBL; BC063397; AAH63397.2; -; mRNA. DR EMBL; BC128452; AAI28453.1; -; mRNA. DR EMBL; BC128453; AAI28454.1; -; mRNA. DR PIR; S55053; S55053. DR RefSeq; NP_003086.1; -. DR UniGene; Hs.105465; -. DR HSSP; P54999; 1N9S. DR IntAct; P62306; -. DR PeptideAtlas; P62306; -. DR Ensembl; ENSG00000139343; Homo sapiens. DR GeneID; 6636; -. DR KEGG; hsa:6636; -. DR H-InvDB; HIX0036777; -. DR HGNC; HGNC:11162; SNRPF. DR MIM; 603541; gene. DR PharmGKB; PA36003; -. DR Reactome; REACT_11052; Metabolism of non-coding RNA. DR Reactome; REACT_1675; mRNA Processing. DR Reactome; REACT_1788; Transcription. DR Reactome; REACT_6167; Influenza Infection. DR Reactome; REACT_71; Gene Expression. DR ArrayExpress; P62306; -. DR CleanEx; HS_SNRPF; -. DR GermOnline; ENSG00000139343; Homo sapiens. DR GO; GO:0030532; C:small nuclear ribonucleoprotein complex; IDA:UniProtKB. DR GO; GO:0005681; C:spliceosome; IDA:UniProtKB. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0003723; F:RNA binding; IMP:UniProtKB. DR GO; GO:0008380; P:RNA splicing; IMP:UniProtKB. DR InterPro; IPR006649; Euk_arc_LSM_core. DR InterPro; IPR001163; LSM_snRNP_core. DR InterPro; IPR016487; snRNP_SmF. DR Pfam; PF01423; LSM; 1. DR PIRSF; PIRSF006609; snRNP_SmF; 1. DR SMART; SM00651; Sm; 1. PE 1: Evidence at protein level; KW mRNA processing; mRNA splicing; Nucleus; Ribonucleoprotein; KW RNA-binding; Spliceosome. FT CHAIN 1 86 Small nuclear ribonucleoprotein F. FT /FTId=PRO_0000125536. FT CONFLICT 86 86 E -> D (in Ref. 2; CAG33032). SQ SEQUENCE 86 AA; 9725 MW; 416B88D575DAE58A CRC64; MSLPLNPKPF LNGLTGKPVM VKLKWGMEYK GYLVSVDGYM NMQLANTEEY IDGALSGHLG EVLIRCNNVL YIRGVEEEEE DGEMRE //