ID AKH_DROME Reviewed; 79 AA. AC P61855; P17975; Q9VZH6; DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot. DT 07-JUN-2004, sequence version 1. DT 01-SEP-2009, entry version 43. DE RecName: Full=Adipokinetic hormone; DE AltName: Full=dAKH; DE AltName: Full=Hypertrehalosaemic hormone; DE Short=HRTH; DE Flags: Precursor; GN Name=Akh; ORFNames=CG1171; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=95394250; PubMed=7664975; DOI=10.1016/0303-7207(95)03492-P; RA Noyes B.E., Schaffer M.H.; RT "Identification and expression of the Drosophila adipokinetic hormone RT gene."; RL Mol. Cell. Endocrinol. 109:133-141(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] RP PROTEIN SEQUENCE OF 23-30, AND AMIDATION. RC STRAIN=Oregon-R; TISSUE=Thorax; RX MEDLINE=90351346; PubMed=2117437; RA Schaffer M.H., Noyes B.E., Slaughter C.A., Thorne G.C., Gaskell S.J.; RT "The fruitfly Drosophila melanogaster contains a novel charged RT adipokinetic-hormone-family peptide."; RL Biochem. J. 269:315-320(1990). RN [5] RP PROTEIN SEQUENCE OF 23-30, AND AMIDATION. RC TISSUE=Larva; RX MEDLINE=22287343; PubMed=12171930; DOI=10.1074/jbc.M206257200; RA Baggerman G., Cerstiaens A., De Loof A., Schoofs L.; RT "Peptidomics of the larval Drosophila melanogaster central nervous RT system."; RL J. Biol. Chem. 277:40368-40374(2002). CC -!- FUNCTION: Probably causes a marked increase in hemolymph CC carbohydrate. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L23764; AAB00099.1; -; Genomic_DNA. DR EMBL; AE014296; AAF47846.1; -; Genomic_DNA. DR PIR; A58656; A58656. DR RefSeq; NP_523918.1; -. DR UniGene; Dm.23971; -. DR STRING; P61855; -. DR PRIDE; P61855; -. DR Ensembl; FBtr0073213; FBpp0073069; FBgn0004552; Drosophila melanogaster. DR GeneID; 38495; -. DR KEGG; dme:Dmel_CG1171; -. DR NMPDR; fig|7227.3.peg.8062; -. DR CTD; 38495; -. DR FlyBase; FBgn0004552; Akh. DR OMA; P61855; CKTSNEM. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-015120-MON; -. DR NextBio; 808945; -. DR GermOnline; CG1171; Drosophila melanogaster. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005184; F:neuropeptide hormone activity; IDA:FlyBase. DR GO; GO:0007218; P:neuropeptide signaling pathway; TAS:FlyBase. DR InterPro; IPR010475; Adipokinetic_2. DR InterPro; IPR002047; Adipokinetic_hormone_CS. DR Pfam; PF06377; Adipokin_hormo; 1. DR PROSITE; PS00256; AKH; 1. PE 1: Evidence at protein level; KW Amidation; Cleavage on pair of basic residues; Complete proteome; KW Direct protein sequencing; Hormone; Neuropeptide; KW Pyrrolidone carboxylic acid; Secreted; Signal. FT SIGNAL 1 22 FT PEPTIDE 23 30 Adipokinetic hormone. FT /FTId=PRO_0000000932. FT PROPEP 34 79 FT /FTId=PRO_0000000933. FT MOD_RES 23 23 Pyrrolidone carboxylic acid. FT MOD_RES 30 30 Tryptophan amide. SQ SEQUENCE 79 AA; 8843 MW; 6EE12D5C71941494 CRC64; MNPKSEVLIA AVLFMLLACV QCQLTFSPDW GKRSVGGAGP GTFFETQQGN CKTSNEMLLE IFRFVQSQAQ LFLDCKHRE //