ID ARP3_HUMAN Reviewed; 418 AA. AC P61158; P32391; DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 01-MAY-2007, entry version 39. DE Actin-like protein 3 (Actin-related protein 3). GN Name=ACTR3; Synonyms=ARP3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=97375667; PubMed=9230079; DOI=10.1083/jcb.138.2.375; RA Welch M.D., Depace A.H., Verma S., Iwamatsu A., Mitchison T.J.; RT "The human Arp2/3 complex is composed of evolutionarily conserved RT subunits and is localized to cellular regions of dynamic actin RT filament assembly."; RL J. Cell Biol. 138:375-384(1997). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Szelei J., Soto A.M., Geck P., Desronvil M., Prechtl N., Weill B., RA Sonnenschein C.; RT "Identification of human estrogen-inducible transcripts from a serum RT resistant variant of breast cancer MCF7 cells."; RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE, RP ACETYLATION AT ALA-2, AND MASS SPECTROMETRY. RC TISSUE=T-cell; RA Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M.; RL Unpublished observations (MAY-2006). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-231, AND MASS RP SPECTROMETRY. RX PubMed=15592455; DOI=10.1038/nbt1046; RA Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., RA Zha X.-M., Polakiewicz R.D., Comb M.J.; RT "Immunoaffinity profiling of tyrosine phosphorylation in cancer RT cells."; RL Nat. Biotechnol. 23:94-101(2005). CC -!- FUNCTION: Part of a complex implicated in the control of actin CC polymerization in cells. CC -!- SUBUNIT: Belongs to a complex composed of ARP2, ARP3, ARPC1, CC ARPC2, ARPC3, ARPC4 and ARPC5. CC -!- INTERACTION: CC O60739:EIF1B; NbExp=1; IntAct=EBI-351428, EBI-1043343; CC -!- SIMILARITY: Belongs to the actin family. ARP3 subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF006083; AAB64188.1; -; mRNA. DR EMBL; AF127773; AAD51904.1; -; mRNA. DR EMBL; BC044590; AAH44590.1; -; mRNA. DR UniGene; Hs.433512; -. DR SMR; P61158; 4-418. DR IntAct; P61158; -. DR OGP; P32391; -. DR Ensembl; ENSG00000115091; Homo sapiens. DR KEGG; hsa:10096; -. DR HGNC; HGNC:170; ACTR3. DR MIM; 604222; gene. DR LinkHub; P61158; -. DR ArrayExpress; P61158; -. DR GermOnline; ENSG00000115091; Homo sapiens. DR RZPD-ProtExp; I0062; -. DR RZPD-ProtExp; IOH26759; -. DR GO; GO:0005885; C:Arp2/3 protein complex; TAS:UniProtKB. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0006928; P:cell motility; TAS:UniProtKB. DR InterPro; IPR004000; Actin_like. DR Gene3D; G3DSA:3.30.420.40; G3DSA:3.30.420.40; 1. DR Gene3D; G3DSA:3.90.640.10; G3DSA:3.90.640.10; 1. DR PANTHER; PTHR11937; Actin_like; 2. DR PANTHER; PTHR11937:SF31; PTHR11937:SF31; 2. DR Pfam; PF00022; Actin; 1. DR SMART; SM00268; ACTIN; 1. DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1. KW Acetylation; ATP-binding; Cytoskeleton; Direct protein sequencing; KW Nucleotide-binding; Phosphorylation; Structural protein. FT INIT_MET 1 1 Removed. FT CHAIN 2 418 Actin-like protein 3. FT /FTId=PRO_0000089079. FT MOD_RES 2 2 N-acetylalanine. FT MOD_RES 231 231 Phosphotyrosine. FT MOD_RES 418 418 Phosphoserine (By similarity). SQ SEQUENCE 418 AA; 47371 MW; 23E5564198B81C63 CRC64; MAGRLPACVV DCGTGYTKLG YAGNTEPQFI IPSCIAIKES AKVGDQAQRR VMKGVDDLDF FIGDEAIEKP TYATKWPIRH GIVEDWDLME RFMEQVIFKY LRAEPEDHYF LLTEPPLNTP ENREYTAEIM FESFNVPGLY IAVQAVLALA ASWTSRQVGE RTLTGTVIDS GDGVTHVIPV AEGYVIGSCI KHIPIAGRDI TYFIQQLLRD REVGIPPEQS LETAKAVKER YSYVCPDLVK EFNKYDTDGS KWIKQYTGIN AISKKEFSID VGYERFLGPE IFFHPEFANP DFTQPISEVV DEVIQNCPID VRRPLYKNIV LSGGSTMFRD FGRRLQRDLK RTVDARLKLS EELSGGRLKP KPIDVQVITH HMQRYAVWFG GSMLASTPEF YQVCHTKKDY EEIGPSICRH NPVFGVMS //