ID ARP3_HUMAN Reviewed; 417 AA. AC P61158; P32391; DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 27-JUN-2006, sequence version 2. DT 31-OCT-2006, entry version 34. DE Actin-like protein 3 (Actin-related protein 3). GN Name=ACTR3; Synonyms=ARP3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=97375667; PubMed=9230079; DOI=10.1083/jcb.138.2.375; RA Welch M.D., Depace A.H., Verma S., Iwamatsu A., Mitchison T.J.; RT "The human Arp2/3 complex is composed of evolutionarily conserved RT subunits and is localized to cellular regions of dynamic actin RT filament assembly."; RL J. Cell Biol. 138:375-384(1997). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Szelei J., Soto A.M., Geck P., Desronvil M., Prechtl N., Weill B., RA Sonnenschein C.; RT "Identification of human estrogen-inducible transcripts from a serum RT resistant variant of breast cancer MCF7 cells."; RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP PROTEIN SEQUENCE OF 1-16, CLEAVAGE OF INITIATOR METHIONINE, RP ACETYLATION AT ALA-1, AND MASS SPECTROMETRY. RC TISSUE=T-cell; RA Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M.; RL Unpublished observations (MAY-2006). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-230, AND MASS RP SPECTROMETRY. RX PubMed=15592455; DOI=10.1038/nbt1046; RA Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., RA Zha X.-M., Polakiewicz R.D., Comb M.J.; RT "Immunoaffinity profiling of tyrosine phosphorylation in cancer RT cells."; RL Nat. Biotechnol. 23:94-101(2005). CC -!- FUNCTION: Part of a complex implicated in the control of actin CC polymerization in cells. CC -!- SUBUNIT: Belongs to a complex composed of ARP2, ARP3, ARPC1, CC ARPC2, ARPC3, ARPC4 and ARPC5. CC -!- SIMILARITY: Belongs to the actin family. ARP3 subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF006083; AAB64188.1; -; mRNA. DR EMBL; AF127773; AAD51904.1; -; mRNA. DR EMBL; BC044590; AAH44590.1; -; mRNA. DR UniGene; Hs.433512; -. DR SMR; P61158; 3-417. DR IntAct; P61158; -. DR OGP; P32391; -. DR Ensembl; ENSG00000115091; Homo sapiens. DR KEGG; hsa:10096; -. DR HGNC; HGNC:170; ACTR3. DR MIM; 604222; gene. DR LinkHub; P61158; -. DR ArrayExpress; P61158; -. DR RZPD-ProtExp; I0062; -. DR RZPD-ProtExp; IOH26759; -. DR GO; GO:0005885; C:Arp2/3 protein complex; TAS:UniProtKB. DR GO; GO:0006928; P:cell motility; TAS:UniProtKB. DR InterPro; IPR004000; Actin_like. DR PANTHER; PTHR11937; Actin_like; 2. DR Pfam; PF00022; Actin; 1. DR SMART; SM00268; ACTIN; 1. DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1. KW Acetylation; ATP-binding; Cytoskeleton; Direct protein sequencing; KW Nucleotide-binding; Phosphorylation; Structural protein. FT INIT_MET 0 0 FT CHAIN 1 417 Actin-like protein 3. FT /FTId=PRO_0000089079. FT MOD_RES 1 1 N-acetylalanine. FT MOD_RES 230 230 Phosphotyrosine. FT MOD_RES 417 417 Phosphoserine (By similarity). SQ SEQUENCE 417 AA; 47240 MW; 9710FF8578E981FF CRC64; AGRLPACVVD CGTGYTKLGY AGNTEPQFII PSCIAIKESA KVGDQAQRRV MKGVDDLDFF IGDEAIEKPT YATKWPIRHG IVEDWDLMER FMEQVIFKYL RAEPEDHYFL LTEPPLNTPE NREYTAEIMF ESFNVPGLYI AVQAVLALAA SWTSRQVGER TLTGTVIDSG DGVTHVIPVA EGYVIGSCIK HIPIAGRDIT YFIQQLLRDR EVGIPPEQSL ETAKAVKERY SYVCPDLVKE FNKYDTDGSK WIKQYTGINA ISKKEFSIDV GYERFLGPEI FFHPEFANPD FTQPISEVVD EVIQNCPIDV RRPLYKNIVL SGGSTMFRDF GRRLQRDLKR TVDARLKLSE ELSGGRLKPK PIDVQVITHH MQRYAVWFGG SMLASTPEFY QVCHTKKDYE EIGPSICRHN PVFGVMS //