ID KR106_HUMAN Reviewed; 365 AA. AC P60371; DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot. DT 09-FEB-2010, sequence version 2. DT 29-SEP-2021, entry version 132. DE RecName: Full=Keratin-associated protein 10-6; DE AltName: Full=High sulfur keratin-associated protein 10.6; DE AltName: Full=Keratin-associated protein 10.6; DE AltName: Full=Keratin-associated protein 18-6; DE AltName: Full=Keratin-associated protein 18.6; GN Name=KRTAP10-6; Synonyms=KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS RP PRO-SER-CYS-CYS-ALA-81 INS AND SER-300. RC TISSUE=Hair root; RX PubMed=15028290; DOI=10.1016/j.ygeno.2003.09.024; RA Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.; RT "A cluster of 21 keratin-associated protein genes within introns of another RT gene on human chromosome 21q22.3."; RL Genomics 83:679-693(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10830953; DOI=10.1038/35012518; RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U., RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.; RT "The DNA sequence of human chromosome 21."; RL Nature 405:311-319(2000). RN [3] RP TISSUE SPECIFICITY. RX PubMed=14962103; DOI=10.1046/j.0022-202x.2003.22128.x; RA Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., RA Schweizer J.; RT "Hair keratin associated proteins: characterization of a second high sulfur RT KAP gene domain on human chromosome 21."; RL J. Invest. Dermatol. 122:147-158(2004). CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are CC embedded in an interfilamentous matrix, consisting of hair keratin- CC associated proteins (KRTAP), which are essential for the formation of a CC rigid and resistant hair shaft through their extensive disulfide bond CC cross-linking with abundant cysteine residues of hair keratins. The CC matrix proteins include the high-sulfur and high-glycine-tyrosine CC keratins. CC -!- SUBUNIT: Interacts with hair keratins. CC -!- INTERACTION: CC P60371; P82987: ADAMTSL3; NbExp=3; IntAct=EBI-12012928, EBI-10221726; CC P60371; Q5T686: AVPI1; NbExp=3; IntAct=EBI-12012928, EBI-8640233; CC P60371; P49759-3: CLK1; NbExp=3; IntAct=EBI-12012928, EBI-11981867; CC P60371; Q9HAZ1: CLK4; NbExp=3; IntAct=EBI-12012928, EBI-633400; CC P60371; Q6P158: DHX57; NbExp=3; IntAct=EBI-12012928, EBI-1051531; CC P60371; Q9UBU2: DKK2; NbExp=3; IntAct=EBI-12012928, EBI-13274770; CC P60371; Q12950: FOXD4; NbExp=3; IntAct=EBI-12012928, EBI-11317801; CC P60371; O96004: HAND1; NbExp=3; IntAct=EBI-12012928, EBI-11320290; CC P60371; Q03014: HHEX; NbExp=3; IntAct=EBI-12012928, EBI-747421; CC P60371; P09067: HOXB5; NbExp=3; IntAct=EBI-12012928, EBI-3893317; CC P60371; A0A384DVV8: KIAA0040; NbExp=3; IntAct=EBI-12012928, EBI-20764875; CC P60371; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-12012928, EBI-8472129; CC P60371; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-12012928, EBI-10172150; CC P60371; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-12012928, EBI-10172511; CC P60371; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-12012928, EBI-11958132; CC P60371; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-12012928, EBI-11993254; CC P60371; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-12012928, EBI-11993296; CC P60371; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-12012928, EBI-11958178; CC P60371; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-12012928, EBI-3958099; CC P60371; Q5T753: LCE1E; NbExp=3; IntAct=EBI-12012928, EBI-11955335; CC P60371; Q5T754: LCE1F; NbExp=3; IntAct=EBI-12012928, EBI-11958008; CC P60371; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-12012928, EBI-11973993; CC P60371; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-12012928, EBI-10246750; CC P60371; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-12012928, EBI-11974495; CC P60371; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-12012928, EBI-10245456; CC P60371; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-12012928, EBI-10246358; CC P60371; Q96ES6: MFSD3; NbExp=3; IntAct=EBI-12012928, EBI-745345; CC P60371; Q13875-3: MOBP; NbExp=3; IntAct=EBI-12012928, EBI-12013470; CC P60371; P07438: MT1B; NbExp=3; IntAct=EBI-12012928, EBI-12015462; CC P60371; P41227: NAA10; NbExp=3; IntAct=EBI-12012928, EBI-747693; CC P60371; Q8IW45: NAXD; NbExp=3; IntAct=EBI-12012928, EBI-8650724; CC P60371; Q969G9: NKD1; NbExp=3; IntAct=EBI-12012928, EBI-1538217; CC P60371; P48645: NMU; NbExp=3; IntAct=EBI-12012928, EBI-10210351; CC P60371; Q9UGY1: NOL12; NbExp=3; IntAct=EBI-12012928, EBI-716098; CC P60371; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-12012928, EBI-748927; CC P60371; Q96AQ6: PBXIP1; NbExp=3; IntAct=EBI-12012928, EBI-740845; CC P60371; Q13526: PIN1; NbExp=3; IntAct=EBI-12012928, EBI-714158; CC P60371; Q6UXX9-2: RSPO2; NbExp=3; IntAct=EBI-12012928, EBI-12009390; CC P60371; Q8TAD8: SNIP1; NbExp=3; IntAct=EBI-12012928, EBI-749336; CC P60371; A0A024R4B0: SPATA3; NbExp=3; IntAct=EBI-12012928, EBI-14123856; CC P60371; Q9BX79-6: STRA6; NbExp=3; IntAct=EBI-12012928, EBI-12140683; CC P60371; Q6EMK4: VASN; NbExp=3; IntAct=EBI-12012928, EBI-10249550; CC P60371; P19544-6: WT1; NbExp=3; IntAct=EBI-12012928, EBI-11745701; CC P60371; Q96MU7: YTHDC1; NbExp=3; IntAct=EBI-12012928, EBI-2849854; CC P60371; O43167: ZBTB24; NbExp=3; IntAct=EBI-12012928, EBI-744471; CC P60371; Q7Z2W4: ZC3HAV1; NbExp=3; IntAct=EBI-12012928, EBI-922540; CC P60371; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-12012928, EBI-11962760; CC P60371; Q8NC26: ZNF114; NbExp=3; IntAct=EBI-12012928, EBI-10265237; CC P60371; P52744: ZNF138; NbExp=3; IntAct=EBI-12012928, EBI-10746567; CC P60371; Q12901: ZNF155; NbExp=3; IntAct=EBI-12012928, EBI-10747670; CC P60371; Q14929: ZNF169; NbExp=3; IntAct=EBI-12012928, EBI-10234472; CC P60371; Q9UK13: ZNF221; NbExp=3; IntAct=EBI-12012928, EBI-14513896; CC P60371; Q16600: ZNF239; NbExp=3; IntAct=EBI-12012928, EBI-8787052; CC P60371; O43296: ZNF264; NbExp=3; IntAct=EBI-12012928, EBI-4395808; CC P60371; Q8ND82: ZNF280C; NbExp=3; IntAct=EBI-12012928, EBI-8831272; CC P60371; Q9NR11-2: ZNF302; NbExp=3; IntAct=EBI-12012928, EBI-12988373; CC P60371; Q9P2F9: ZNF319; NbExp=3; IntAct=EBI-12012928, EBI-11993110; CC P60371; Q8TF45: ZNF418; NbExp=3; IntAct=EBI-12012928, EBI-3446851; CC P60371; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-12012928, EBI-726439; CC P60371; Q96JC4: ZNF479; NbExp=3; IntAct=EBI-12012928, EBI-10820574; CC P60371; Q9ULM2: ZNF490; NbExp=3; IntAct=EBI-12012928, EBI-1105370; CC P60371; Q08ER8: ZNF543; NbExp=3; IntAct=EBI-12012928, EBI-10226133; CC P60371; Q8TA94: ZNF563; NbExp=3; IntAct=EBI-12012928, EBI-11792334; CC P60371; Q8IYB9: ZNF595; NbExp=3; IntAct=EBI-12012928, EBI-2682172; CC P60371; Q6ZNG1: ZNF600; NbExp=3; IntAct=EBI-12012928, EBI-3444696; CC P60371; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-12012928, EBI-12006574; CC P60371; Q499Z4: ZNF672; NbExp=3; IntAct=EBI-12012928, EBI-12146251; CC P60371; Q8IYX0: ZNF679; NbExp=3; IntAct=EBI-12012928, EBI-745567; CC P60371; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-12012928, EBI-11090299; CC P60371; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-12012928, EBI-10251462; CC P60371; Q68DI1: ZNF776; NbExp=3; IntAct=EBI-12012928, EBI-12878746; CC P60371; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-12012928, EBI-10240849; CC P60371; O43257: ZNHIT1; NbExp=3; IntAct=EBI-12012928, EBI-347522; CC -!- TISSUE SPECIFICITY: Restricted to a narrow region of the hair fiber CC cuticle, lying approximately 20 cell layers above the apex of the CC dermal papilla of the hair root; not detected in any other tissues. CC {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}. CC -!- SIMILARITY: Belongs to the KRTAP type 10 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB076353; BAD01540.1; -; mRNA. DR EMBL; AL773602; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS42959.1; -. DR RefSeq; NP_941961.3; NM_198688.3. DR BioGRID; 132125; 73. DR IntAct; P60371; 73. DR STRING; 9606.ENSP00000383219; -. DR iPTMnet; P60371; -. DR PhosphoSitePlus; P60371; -. DR BioMuta; KRTAP10-6; -. DR DMDM; 288558812; -. DR MassIVE; P60371; -. DR PaxDb; P60371; -. DR PeptideAtlas; P60371; -. DR PRIDE; P60371; -. DR ProteomicsDB; 57200; -. DR Antibodypedia; 78046; 1 antibodies. DR DNASU; 386674; -. DR Ensembl; ENST00000400368; ENSP00000383219; ENSG00000188155. DR GeneID; 386674; -. DR KEGG; hsa:386674; -. DR UCSC; uc032qbq.1; human. DR CTD; 386674; -. DR GeneCards; KRTAP10-6; -. DR HGNC; HGNC:20523; KRTAP10-6. DR HPA; ENSG00000188155; Tissue enriched (skin). DR neXtProt; NX_P60371; -. DR PharmGKB; PA134871340; -. DR VEuPathDB; HostDB:ENSG00000188155; -. DR eggNOG; KOG4726; Eukaryota. DR InParanoid; P60371; -. DR OrthoDB; 1629708at2759; -. DR PhylomeDB; P60371; -. DR PathwayCommons; P60371; -. DR Reactome; R-HSA-6805567; Keratinization. DR BioGRID-ORCS; 386674; 24 hits in 922 CRISPR screens. DR GenomeRNAi; 386674; -. DR Pharos; P60371; Tdark. DR PRO; PR:P60371; -. DR Proteomes; UP000005640; Chromosome 21. DR RNAct; P60371; protein. DR Bgee; ENSG00000188155; Expressed in liver and 10 other tissues. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0045095; C:keratin filament; IEA:InterPro. DR InterPro; IPR002494; KAP. DR PANTHER; PTHR23262; PTHR23262; 5. DR Pfam; PF13885; Keratin_B2_2; 4. PE 1: Evidence at protein level; KW Keratin; Reference proteome; Repeat. FT CHAIN 1..365 FT /note="Keratin-associated protein 10-6" FT /id="PRO_0000185214" FT REPEAT 41..45 FT /note="1" FT REPEAT 46..50 FT /note="2" FT REPEAT 67..71 FT /note="3" FT REPEAT 89..93 FT /note="4" FT REPEAT 99..103 FT /note="5" FT REPEAT 109..113 FT /note="6" FT REPEAT 114..118 FT /note="7" FT REPEAT 119..123 FT /note="8" FT REPEAT 124..128 FT /note="9" FT REPEAT 129..133 FT /note="10" FT REPEAT 135..139 FT /note="11" FT REPEAT 145..149 FT /note="12" FT REPEAT 155..159 FT /note="13" FT REPEAT 160..164 FT /note="14" FT REPEAT 172..176 FT /note="15" FT REPEAT 186..190 FT /note="16" FT REPEAT 208..212 FT /note="17" FT REPEAT 218..222 FT /note="18" FT REPEAT 228..232 FT /note="19" FT REPEAT 233..237 FT /note="20" FT REPEAT 238..242 FT /note="21" FT REPEAT 250..254 FT /note="22" FT REPEAT 260..264 FT /note="23" FT REPEAT 270..274 FT /note="24" FT REPEAT 282..286 FT /note="25" FT REPEAT 292..296 FT /note="26" FT REPEAT 297..301 FT /note="27" FT REPEAT 316..320 FT /note="28" FT REPEAT 334..338 FT /note="29" FT REGION 41..338 FT /note="29 X 5 AA repeats of C-C-X(3)" FT VARIANT 68 FT /note="C -> S (in dbSNP:rs13051409)" FT /id="VAR_060049" FT VARIANT 74 FT /note="P -> S (in dbSNP:rs13050443)" FT /id="VAR_060050" FT VARIANT 81 FT /note="C -> CPSCCA" FT /id="VAR_017699" FT VARIANT 159 FT /note="V -> I (in dbSNP:rs233306)" FT /id="VAR_057649" FT VARIANT 300 FT /note="P -> S (in dbSNP:rs465279)" FT /evidence="ECO:0000269|PubMed:15028290" FT /id="VAR_062533" SQ SEQUENCE 365 AA; 36791 MW; 480F13F202A3BEA2 CRC64; MAASTMSVCS SDLSYGSRVC LPGSCDSCSD SWQVDDCPES CCEPPCCAPA PCLSLVCTPV SRVSSPCCPV TCEPSPCQSG CTSSCTPSCC QQSSCQLACC ASSPCQQACC VPVCCKTVCC KPVCCVSVCC GDSSCCQQSS CQSACCTSSP CQQACCVPVC CKPVCSGISS SCCQQSSCVS CVSSPCCQAV CEPSPCQSGC TSSCTPSCCQ QSSCQPTCCT SSPCQQACCV PVCCVPVCCV PTCSEDSSSC CQQSSCQPAC CTSSPCQHAC CVPVCSGAST SCCQQSSCQP ACCTASCCRP SSSVSLLCHP VCKSTCCVPV PSCGASASSC QPSCCRTASC VSLLCRPMCS RPACYSLCSG QKSSC //