ID DB131_HUMAN Reviewed; 70 AA. AC P59861; DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot. DT 09-FEB-2010, sequence version 2. DT 03-SEP-2014, entry version 77. DE RecName: Full=Beta-defensin 131; DE AltName: Full=Beta-defensin 31; DE Short=DEFB-31; DE AltName: Full=Defensin, beta 131; DE Flags: Precursor; GN Name=DEFB131; Synonyms=DEFB31; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX PubMed=12600824; DOI=10.1165/rcmb.2002-0205OC; RA Kao C.Y., Chen Y., Zhao Y.H., Wu R.; RT "ORFeome-based search of airway epithelial cell-specific novel human RT beta-defensin genes."; RL Am. J. Respir. Cell Mol. Biol. 29:71-80(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Has antibacterial activity (Potential). CC -!- SUBCELLULAR LOCATION: Secreted (Potential). CC -!- TISSUE SPECIFICITY: Highly expressed in testis. Is moderately CC expressed in the prostate and small intestine. CC -!- SIMILARITY: Belongs to the beta-defensin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF529414; AAQ09523.1; -; mRNA. DR EMBL; AC116655; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC160155; AAI60155.1; -; mRNA. DR CCDS; CCDS43213.1; -. DR RefSeq; NP_001035538.2; NM_001040448.2. DR UniGene; Hs.590200; -. DR ProteinModelPortal; P59861; -. DR STRING; 9606.ENSP00000335538; -. DR DMDM; 288558809; -. DR PRIDE; P59861; -. DR DNASU; 644414; -. DR Ensembl; ENST00000334879; ENSP00000335538; ENSG00000186146. DR GeneID; 644414; -. DR KEGG; hsa:644414; -. DR UCSC; uc011bwt.2; human. DR CTD; 644414; -. DR GeneCards; GC04P009446; -. DR H-InvDB; HIX0031394; -. DR HGNC; HGNC:18108; DEFB131. DR HPA; HPA052257; -. DR neXtProt; NX_P59861; -. DR PharmGKB; PA38504; -. DR eggNOG; NOG79710; -. DR HOGENOM; HOG000112162; -. DR HOVERGEN; HBG051313; -. DR InParanoid; P59861; -. DR OMA; ADFIERC; -. DR OrthoDB; EOG7NGQF7; -. DR PhylomeDB; P59861; -. DR TreeFam; TF341399; -. DR Reactome; REACT_115846; Defensins. DR Reactome; REACT_115897; Beta defensins. DR NextBio; 116219; -. DR PRO; PR:P59861; -. DR CleanEx; HS_DEFB131; -. DR Genevestigator; P59861; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW. DR InterPro; IPR025933; Beta_defensin. DR Pfam; PF13841; Defensin_beta_2; 1. PE 2: Evidence at transcript level; KW Antibiotic; Antimicrobial; Complete proteome; Defensin; KW Disulfide bond; Reference proteome; Secreted; Signal. FT SIGNAL 1 22 Potential. FT PEPTIDE 23 70 Beta-defensin 131. FT /FTId=PRO_0000007006. FT DISULFID 29 56 By similarity. FT DISULFID 36 50 By similarity. FT DISULFID 40 57 By similarity. FT CONFLICT 20 20 A -> G (in Ref. 1; AAQ09523). SQ SEQUENCE 70 AA; 8199 MW; 2A3DC536A4924F14 CRC64; MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYHCRLKC NADEHAIRYC ADFSICCKLK IIEIDGQKKW //