ID DB131_HUMAN Reviewed; 70 AA. AC P59861; DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot. DT 26-SEP-2003, sequence version 1. DT 24-NOV-2009, entry version 45. DE RecName: Full=Beta-defensin 131; DE AltName: Full=Defensin, beta 131; DE AltName: Full=Beta-defensin 31; DE AltName: Full=DEFB-31; DE Flags: Precursor; GN Name=DEFB131; Synonyms=DEFB31; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX MEDLINE=22705149; PubMed=12600824; DOI=10.1165/rcmb.2002-0205OC; RA Kao C.Y., Chen Y., Zhao Y.H., Wu R.; RT "ORFeome-based search of airway epithelial cell-specific novel human RT beta-defensin genes."; RL Am. J. Respir. Cell Mol. Biol. 29:71-80(2003). CC -!- FUNCTION: Has antibacterial activity (Potential). CC -!- SUBCELLULAR LOCATION: Secreted (Potential). CC -!- TISSUE SPECIFICITY: Highly expressed in testis. Is moderately CC expressed in the prostate and small intestine. CC -!- SIMILARITY: Belongs to the beta-defensin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF529414; AAQ09523.1; -; mRNA. DR IPI; IPI00739683; -. DR RefSeq; NP_001035538.2; -. DR UniGene; Hs.590200; -. DR Ensembl; ENST00000334879; ENSP00000335538; ENSG00000186146; Homo sapiens. DR GeneID; 644414; -. DR KEGG; hsa:644414; -. DR UCSC; uc003glz.1; human. DR CTD; 644414; -. DR GeneCards; GC04P009055; -. DR GeneCards; GC08M011938; -. DR GeneCards; GC11P071267; -. DR H-InvDB; HIX0031394; -. DR HGNC; HGNC:18108; DEFB131. DR PharmGKB; PA38504; -. DR HOGENOM; P59861; -. DR HOVERGEN; P59861; -. DR NextBio; 116219; -. DR CleanEx; HS_DEFB131; -. DR Genevestigator; P59861; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW. PE 2: Evidence at transcript level; KW Antibiotic; Antimicrobial; Complete proteome; Defensin; KW Disulfide bond; Secreted; Signal. FT SIGNAL 1 22 Potential. FT PEPTIDE 23 70 Beta-defensin 131. FT /FTId=PRO_0000007006. FT DISULFID 29 56 By similarity. FT DISULFID 36 50 By similarity. FT DISULFID 40 57 By similarity. SQ SEQUENCE 70 AA; 8185 MW; 2A3DC1A07FFB6F14 CRC64; MRVLFFVFGV LSLMFTVPPG RSFISNDECP SEYYHCRLKC NADEHAIRYC ADFSICCKLK IIEIDGQKKW //