ID   OR2B6_HUMAN             Reviewed;         313 AA.
AC   P58173; O43883; Q6IF89; Q9H5B0;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 1.
DT   03-MAY-2023, entry version 166.
DE   RecName: Full=Olfactory receptor 2B6;
DE   AltName: Full=Hs6M1-32;
DE   AltName: Full=Olfactory receptor 2B1;
DE   AltName: Full=Olfactory receptor 2B5;
DE   AltName: Full=Olfactory receptor 5-40;
DE            Short=OR5-40;
DE   AltName: Full=Olfactory receptor 6-31;
DE            Short=OR6-31;
DE   AltName: Full=Olfactory receptor OR6-4;
GN   Name=OR2B6; Synonyms=OR2B1, OR2B1P, OR2B5, OR2B6P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=9500546; DOI=10.1038/ng0398-243;
RA   Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
RA   Demaille J.G., Giorgi D.;
RT   "Distribution of olfactory receptor genes in the human genome.";
RL   Nat. Genet. 18:243-250(1998).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR2B6";
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DR   EMBL; AL133267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC109251; AAI09252.1; -; mRNA.
DR   EMBL; BC110457; AAI10458.1; -; mRNA.
DR   EMBL; U86270; AAC39628.1; -; Genomic_DNA.
DR   EMBL; BK004373; DAA04771.1; -; Genomic_DNA.
DR   CCDS; CCDS4642.1; -.
DR   RefSeq; NP_036499.1; NM_012367.1.
DR   AlphaFoldDB; P58173; -.
DR   SMR; P58173; -.
DR   IntAct; P58173; 1.
DR   STRING; 9606.ENSP00000244623; -.
DR   GlyCosmos; P58173; 1 site, No reported glycans.
DR   GlyGen; P58173; 1 site.
DR   iPTMnet; P58173; -.
DR   PhosphoSitePlus; P58173; -.
DR   BioMuta; OR2B6; -.
DR   DMDM; 14423785; -.
DR   PaxDb; P58173; -.
DR   PeptideAtlas; P58173; -.
DR   ProteomicsDB; 57052; -.
DR   Antibodypedia; 67797; 64 antibodies from 17 providers.
DR   DNASU; 26212; -.
DR   Ensembl; ENST00000244623.1; ENSP00000244623.1; ENSG00000124657.1.
DR   GeneID; 26212; -.
DR   KEGG; hsa:26212; -.
DR   MANE-Select; ENST00000244623.1; ENSP00000244623.1; NM_012367.1; NP_036499.1.
DR   UCSC; uc011dkx.2; human.
DR   AGR; HGNC:8241; -.
DR   CTD; 26212; -.
DR   GeneCards; OR2B6; -.
DR   HGNC; HGNC:8241; OR2B6.
DR   HPA; ENSG00000124657; Not detected.
DR   neXtProt; NX_P58173; -.
DR   OpenTargets; ENSG00000124657; -.
DR   PharmGKB; PA32144; -.
DR   VEuPathDB; HostDB:ENSG00000124657; -.
DR   eggNOG; ENOG502SI2C; Eukaryota.
DR   GeneTree; ENSGT01070000253780; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; P58173; -.
DR   OMA; QMLVNLC; -.
DR   OrthoDB; 4790557at2759; -.
DR   PhylomeDB; P58173; -.
DR   TreeFam; TF336512; -.
DR   PathwayCommons; P58173; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; P58173; -.
DR   BioGRID-ORCS; 26212; 6 hits in 745 CRISPR screens.
DR   GeneWiki; OR2B6; -.
DR   GenomeRNAi; 26212; -.
DR   Pharos; P58173; Tdark.
DR   PRO; PR:P58173; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; P58173; protein.
DR   Bgee; ENSG00000124657; Expressed in mucosa of transverse colon and 48 other tissues.
DR   ExpressionAtlas; P58173; baseline and differential.
DR   Genevisible; P58173; HS.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15947; 7tmA_OR2B-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF202; OLFACTORY RECEPTOR 2B6; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..313
FT                   /note="Olfactory receptor 2B6"
FT                   /id="PRO_0000150462"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..313
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         117
FT                   /note="V -> I (in dbSNP:rs7767176)"
FT                   /id="VAR_053131"
FT   VARIANT         270
FT                   /note="Q -> R (in dbSNP:rs9380030)"
FT                   /id="VAR_024090"
SQ   SEQUENCE   313 AA;  35414 MW;  71D459541ACF5301 CRC64;
     MNWVNDSIIQ EFILLGFSDR PWLEFPLLVV FLISYTVTIF GNLTIILVSR LDTKLHTPMY
     FFLTNLSLLD LCYTTCTVPQ MLVNLCSIRK VISYRGCVAQ LFIFLALGAT EYLLLAVMSF
     DRFVAICRPL HYSVIMHQRL CLQLAAASWV TGFSNSVWLS TLTLQLPLCD PYVIDHFLCE
     VPALLKLSCV ETTANEAELF LVSELFHLIP LTLILISYAF IVRAVLRIQS AEGRQKAFGT
     CGSHLIVVSL FYSTAVSVYL QPPSPSSKDQ GKMVSLFYGI IAPMLNPLIY TLRNKEVKEG
     FKRLVARVFL IKK
//