ID MOT4_MOUSE Reviewed; 470 AA. AC P57787; Q9ES80; Q9ESF8; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 27-APR-2001, sequence version 1. DT 02-OCT-2007, entry version 43. DE Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member DE 3). GN Name=Slc16a3; Synonyms=Mct4; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H; TISSUE=Skeletal muscle; RA Yoon H., Philp N.J.; RT "Cloning and expression of mouse MCT3 and MCT4."; RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=129; TISSUE=Mammary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Proton-linked monocarboxylate transporter. Catalyzes the CC rapid transport across the plasma membrane of many CC monocarboxylates such as lactate, pyruvate, branched-chain oxo CC acids derived from leucine, valine and isoleucine, and the ketone CC bodies acetoacetate, beta-hydroxybutyrate and acetate (By CC similarity). CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein CC (By similarity). CC -!- SIMILARITY: Belongs to the major facilitator superfamily. CC Monocarboxylate porter (TC 2.A.1.13) family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF178954; AAG24271.1; -; mRNA. DR EMBL; AF204397; AAF67525.1; -; Genomic_DNA. DR EMBL; BC046525; AAH46525.1; -; mRNA. DR RefSeq; NP_001033742.1; -. DR RefSeq; NP_001033743.1; -. DR RefSeq; NP_109621.1; -. DR UniGene; Mm.28632; -. DR Ensembl; ENSMUSG00000025161; Mus musculus. DR MGI; MGI:1933438; Slc16a3. DR ArrayExpress; P57787; -. DR GermOnline; ENSMUSG00000025161; Mus musculus. DR InterPro; IPR007114; MFS. DR InterPro; IPR011701; MFS_1. DR InterPro; IPR004743; Monocarb_transpt. DR Pfam; PF07690; MFS_1; 1. DR TIGRFAMs; TIGR00892; 2A0113; 1. DR PROSITE; PS50850; MFS; 1. PE 2: Evidence at transcript level; KW Membrane; Phosphorylation; Symport; Transmembrane; Transport. FT CHAIN 1 470 Monocarboxylate transporter 4. FT /FTId=PRO_0000211395. FT TOPO_DOM 1 17 Cytoplasmic (Potential). FT TRANSMEM 18 38 Potential. FT TOPO_DOM 39 61 Extracellular (Potential). FT TRANSMEM 62 82 Potential. FT TOPO_DOM 83 84 Cytoplasmic (Potential). FT TRANSMEM 85 105 Potential. FT TOPO_DOM 106 109 Extracellular (Potential). FT TRANSMEM 110 130 Potential. FT TOPO_DOM 131 149 Cytoplasmic (Potential). FT TRANSMEM 150 170 Potential. FT TOPO_DOM 171 179 Extracellular (Potential). FT TRANSMEM 180 200 Potential. FT TOPO_DOM 201 231 Cytoplasmic (Potential). FT TRANSMEM 232 252 Potential. FT TOPO_DOM 253 267 Extracellular (Potential). FT TRANSMEM 268 288 Potential. FT TOPO_DOM 289 298 Cytoplasmic (Potential). FT TRANSMEM 299 319 Potential. FT TOPO_DOM 320 321 Extracellular (Potential). FT TRANSMEM 322 342 Potential. FT TOPO_DOM 343 355 Cytoplasmic (Potential). FT TRANSMEM 356 376 Potential. FT TOPO_DOM 377 391 Extracellular (Potential). FT TRANSMEM 392 412 Potential. FT TOPO_DOM 413 470 Cytoplasmic (Potential). FT MOD_RES 465 465 Phosphothreonine (By similarity). FT MOD_RES 469 469 Phosphoserine (By similarity). SQ SEQUENCE 470 AA; 50373 MW; 34E872AC1C625DE7 CRC64; MGGAVVDEGP TGIKAPDGGW GWAVLFGCFI ITGFSYAFPK AVSVFFKELM HEFGIGYSDT AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL GMVAASFCRS IIQIYLTTGV ITGLGLALNF QPSLIMLNRY FNKRRPIANG LAAAGSPVFL CALSPLGQLL QDHYGWRGGF LILGGLLLNC CVCAALMRPL VAPQVGGGTE PRGPQRPPQR LLDLSVFRDR GFLIYAVAAS IMVLGLFVPP VFVVSYAKDM GVPDTKAAFL LTILGFIDIF ARPTAGFITG LKKVRPYSVY LFSFAMFFNG FTDLTGSTAT DYGGLVVFCI FFGISYGMVG ALQFEVLMAI VGTQKFSSAI GLVLLLEAVA VLIGPPSGGK LLDATKVYKY VFILAGAEVL TSSLVLLLGN FFCIGKRKRP EVTEPEEVAS EEKLHKPPVD VGVDSREVEH FLKAEPEKNG EVVHTPETSV //