ID ICBR_HUMAN STANDARD; PRT; 90 AA. AC P57730; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Caspase-1 inhibitor Iceberg. GN ICEBERG. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=20503847; PubMed=11051551; RA Humke E.W., Shriver S.K., Starovasnik M.A., Fairbrother W.J., RA Dixit V.M.; RT "ICEBERG: a novel inhibitor of interleukin-1beta generation."; RL Cell 103:99-111(2000). CC -!- FUNCTION: INHIBITS GENERATION OF IL-1BETA BY INTERACTING WITH CC CASPASE-1 AND PREVENTING ITS ASSOCIATION WITH RIP2. CC -!- TISSUE SPECIFICITY: PRIMARILY EXPRESSED IN THE HEART AND PLACENTA. CC -!- SIMILARITY: Contains 1 CARD domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF208005; AAG23528.1; -. DR MIM; 605354; -. DR GO; GO:0006954; P:inflammatory response; NAS. DR InterPro; IPR001315; CARD. DR Pfam; PF00619; CARD; 1. DR SMART; SM00114; CARD; 1. DR PROSITE; PS50209; CARD; 1. KW Thiol protease inhibitor. FT DOMAIN 1 90 CARD. SQ SEQUENCE 90 AA; 10138 MW; 7E74C74263367101 CRC64; MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH //