ID ICBR_HUMAN Reviewed; 90 AA. AC P57730; DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot. DT 11-JAN-2001, sequence version 1. DT 23-JAN-2007, entry version 43. DE Caspase-1 inhibitor Iceberg. GN Name=ICEBERG; ORFNames=UNQ5804/PRO19611; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND STRUCTURE BY NMR. RX MEDLINE=20503847; PubMed=11051551; DOI=10.1016/S0092-8674(00)00108-2; RA Humke E.W., Shriver S.K., Starovasnik M.A., Fairbrother W.J., RA Dixit V.M.; RT "ICEBERG: a novel inhibitor of interleukin-1beta generation."; RL Cell 103:99-111(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). CC -!- FUNCTION: Inhibits generation of IL-1beta by interacting with CC caspase-1 and preventing its association with RIP2. CC -!- TISSUE SPECIFICITY: Primarily expressed in the heart and placenta. CC -!- SIMILARITY: Contains 1 CARD domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF208005; AAG23528.1; -; mRNA. DR EMBL; AY358231; AAQ88598.1; -; mRNA. DR UniGene; Hs.56279; -. DR PDB; 1DGN; NMR; A=2-90. DR Ensembl; ENSG00000118168; Homo sapiens. DR KEGG; hsa:59082; -. DR MIM; 605354; gene. DR LinkHub; P57730; -. DR ArrayExpress; P57730; -. DR GermOnline; ENSG00000118168; Homo sapiens. DR RZPD-ProtExp; IOH42984; -. DR GO; GO:0006954; P:inflammatory response; NAS:UniProtKB. DR InterPro; IPR001315; CARD. DR InterPro; IPR011029; DEATH_like. DR InterPro; IPR002398; Pept_C14_p45. DR Gene3D; G3DSA:1.10.533.10; DEATH_like; 1. DR PANTHER; PTHR10454; Pept_C14_p45; 1. DR Pfam; PF00619; CARD; 1. DR SMART; SM00114; CARD; 1. DR PROSITE; PS50209; CARD; 1. KW 3D-structure; Protease inhibitor; Thiol protease inhibitor. FT CHAIN 1 90 Caspase-1 inhibitor Iceberg. FT /FTId=PRO_0000084145. FT DOMAIN 1 90 CARD. FT HELIX 5 8 FT TURN 9 9 FT HELIX 10 14 FT TURN 15 16 FT HELIX 19 32 FT TURN 33 33 FT HELIX 37 44 FT TURN 45 45 FT HELIX 50 63 FT TURN 64 64 FT HELIX 66 79 FT TURN 81 82 FT HELIX 83 87 SQ SEQUENCE 90 AA; 10138 MW; 7E74C74263367101 CRC64; MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH //