ID CAR18_HUMAN Reviewed; 90 AA. AC P57730; A2RRF8; DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot. DT 11-JAN-2001, sequence version 1. DT 05-OCT-2016, entry version 118. DE RecName: Full=Caspase recruitment domain-containing protein 18; DE AltName: Full=Caspase-1 inhibitor Iceberg; GN Name=CARD18; Synonyms=ICEBERG; ORFNames=UNQ5804/PRO19611; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], STRUCTURE BY NMR, FUNCTION, INTERACTION RP WITH CASP1, INDUCTION, AND TISSUE SPECIFICITY. RX PubMed=11051551; DOI=10.1016/S0092-8674(00)00108-2; RA Humke E.W., Shriver S.K., Starovasnik M.A., Fairbrother W.J., RA Dixit V.M.; RT "ICEBERG: a novel inhibitor of interleukin-1beta generation."; RL Cell 103:99-111(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP INTERACTION WITH CARD8. RX PubMed=11821383; DOI=10.1074/jbc.M107811200; RA Razmara M., Srinivasula S.M., Wang L., Poyet J.-L., Geddes B.J., RA DiStefano P.S., Bertin J., Alnemri E.S.; RT "CARD-8 protein, a new CARD family member that regulates caspase-1 RT activation and apoptosis."; RL J. Biol. Chem. 277:13952-13958(2002). CC -!- FUNCTION: Inhibits generation of IL-1-beta by interacting with CC caspase-1 and preventing its association with RIP2. Down-regulates CC the release of IL1B. {ECO:0000269|PubMed:11051551}. CC -!- SUBUNIT: Interacts with pro-CASP1. Interacts with CARD8. CC {ECO:0000269|PubMed:11051551, ECO:0000269|PubMed:11821383}. CC -!- TISSUE SPECIFICITY: Primarily expressed in the heart and placenta. CC {ECO:0000269|PubMed:11051551}. CC -!- INDUCTION: Up-regulated in response to TNF and bacterial CC lipopolysaccharides (LPS). {ECO:0000269|PubMed:11051551}. CC -!- SIMILARITY: Contains 1 CARD domain. {ECO:0000255|PROSITE- CC ProRule:PRU00046}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF208005; AAG23528.1; -; mRNA. DR EMBL; AY358231; AAQ88598.1; -; mRNA. DR EMBL; BC131610; AAI31611.1; -; mRNA. DR CCDS; CCDS53705.1; -. DR RefSeq; NP_067546.1; NM_021571.3. DR UniGene; Hs.56279; -. DR PDB; 1DGN; NMR; -; A=2-90. DR PDBsum; 1DGN; -. DR ProteinModelPortal; P57730; -. DR SMR; P57730; 2-90, 16-79, 21-85. DR MINT; MINT-231364; -. DR STRING; 9606.ENSP00000436691; -. DR iPTMnet; P57730; -. DR PhosphoSite; P57730; -. DR BioMuta; CARD18; -. DR DMDM; 12230142; -. DR PaxDb; P57730; -. DR PeptideAtlas; P57730; -. DR PRIDE; P57730; -. DR Ensembl; ENST00000530950; ENSP00000436691; ENSG00000255501. DR GeneID; 59082; -. DR KEGG; hsa:59082; -. DR UCSC; uc021qpy.2; human. DR CTD; 59082; -. DR GeneCards; CARD18; -. DR HGNC; HGNC:28861; CARD18. DR HPA; HPA038582; -. DR MIM; 605354; gene. DR neXtProt; NX_P57730; -. DR PharmGKB; PA164717642; -. DR eggNOG; KOG3573; Eukaryota. DR eggNOG; ENOG410ZQIE; LUCA. DR GeneTree; ENSGT00510000049857; -. DR HOVERGEN; HBG006113; -. DR InParanoid; P57730; -. DR KO; K12806; -. DR OMA; EDMNKVR; -. DR OrthoDB; EOG091G10JS; -. DR PhylomeDB; P57730; -. DR EvolutionaryTrace; P57730; -. DR GenomeRNAi; 59082; -. DR PRO; PR:P57730; -. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000255501; -. DR CleanEx; HS_CARD18; -. DR ExpressionAtlas; P57730; baseline and differential. DR Genevisible; P57730; HS. DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; NAS:UniProtKB. DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro. DR Gene3D; 1.10.533.10; -; 1. DR InterPro; IPR001315; CARD. DR InterPro; IPR011029; DEATH-like_dom. DR Pfam; PF00619; CARD; 1. DR SUPFAM; SSF47986; SSF47986; 1. DR PROSITE; PS50209; CARD; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Protease inhibitor; KW Reference proteome; Thiol protease inhibitor. FT CHAIN 1 90 Caspase recruitment domain-containing FT protein 18. FT /FTId=PRO_0000084145. FT DOMAIN 1 90 CARD. {ECO:0000255|PROSITE- FT ProRule:PRU00046}. FT HELIX 5 8 {ECO:0000244|PDB:1DGN}. FT HELIX 10 14 {ECO:0000244|PDB:1DGN}. FT HELIX 19 32 {ECO:0000244|PDB:1DGN}. FT HELIX 37 44 {ECO:0000244|PDB:1DGN}. FT HELIX 50 63 {ECO:0000244|PDB:1DGN}. FT HELIX 66 79 {ECO:0000244|PDB:1DGN}. FT HELIX 83 87 {ECO:0000244|PDB:1DGN}. SQ SEQUENCE 90 AA; 10138 MW; 7E74C74263367101 CRC64; MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH //