ID ICBR_HUMAN STANDARD; PRT; 90 AA. AC P57730; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-MAR-2004 (Rel. 43, Last annotation update) DE Caspase-1 inhibitor Iceberg (UNQ5804/PRO19611). GN ICEBERG. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A., AND STRUCTURE BY NMR. RX MEDLINE=20503847; PubMed=11051551; RA Humke E.W., Shriver S.K., Starovasnik M.A., Fairbrother W.J., RA Dixit V.M.; RT "ICEBERG: a novel inhibitor of interleukin-1beta generation."; RL Cell 103:99-111(2000). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=22887296; PubMed=12975309; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D., RA Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A., Wood W.I., RA Godowski P.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). CC -!- FUNCTION: Inhibits generation of IL-1beta by interacting with CC caspase-1 and preventing its association with RIP2. CC -!- TISSUE SPECIFICITY: Primarily expressed in the heart and placenta. CC -!- SIMILARITY: Contains 1 CARD domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF208005; AAG23528.1; -. DR EMBL; AY358231; AAQ88598.1; -. DR PDB; 1DGN; 09-OCT-00. DR MIM; 605354; -. DR GO; GO:0006954; P:inflammatory response; NAS. DR InterPro; IPR001315; CARD. DR Pfam; PF00619; CARD; 1. DR SMART; SM00114; CARD; 1. DR PROSITE; PS50209; CARD; 1. KW Thiol protease inhibitor; 3D-structure. FT DOMAIN 1 90 CARD. SQ SEQUENCE 90 AA; 10138 MW; 7E74C74263367101 CRC64; MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH //