ID GLRA1_BOVIN Reviewed; 457 AA.
AC P57695; Q9GKE9; Q9GKF0;
DT 08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 08-DEC-2000, sequence version 1.
DT 31-OCT-2012, entry version 97.
DE RecName: Full=Glycine receptor subunit alpha-1;
DE AltName: Full=Glycine receptor 48 kDa subunit;
DE AltName: Full=Glycine receptor strychnine-binding subunit;
DE Flags: Precursor;
GN Name=GLRA1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A AND B), AND
RP DISEASE.
RX MEDLINE=21109390; PubMed=11178872; DOI=10.1006/mcne.2000.0934;
RA Pierce K.D., Handford C.A., Morris R., Vafa B., Dennis J.A.,
RA Healy P.J., Schofield P.R.;
RT "A nonsense mutation in the alpha1 subunit of the inhibitory glycine
RT receptor associated with bovine myoclonus.";
RL Mol. Cell. Neurosci. 17:354-363(2001).
CC -!- FUNCTION: The glycine receptor is a neurotransmitter-gated ion
CC channel. Binding of glycine to its receptor increases the chloride
CC conductance and thus produces hyperpolarization (inhibition of
CC neuronal firing) (By similarity).
CC -!- SUBUNIT: Pentamer composed of alpha and beta subunits (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC membrane; Multi-pass membrane protein (By similarity). Cell
CC membrane; Multi-pass membrane protein (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P57695-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P57695-2; Sequence=VSP_021141;
CC -!- DISEASE: Note=Defects in GLRA1 are the cause of inherited
CC congenital myoclonus of Poll Hereford calves. It is an autosomal
CC recessive disease characterized by hyperesthesia and myoclonic
CC jerks of the skeletal musculature that occur both spontaneously
CC and in response to sensory stimuli.
CC -!- MISCELLANEOUS: The alpha subunit binds strychnine.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-
CC subfamily.
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DR EMBL; AF268375; AAG14346.1; -; mRNA.
DR EMBL; AF268366; AAG41140.1; -; Genomic_DNA.
DR EMBL; AF268358; AAG41140.1; JOINED; Genomic_DNA.
DR EMBL; AF268360; AAG41140.1; JOINED; Genomic_DNA.
DR EMBL; AF268361; AAG41140.1; JOINED; Genomic_DNA.
DR EMBL; AF268359; AAG41140.1; JOINED; Genomic_DNA.
DR EMBL; AF268362; AAG41140.1; JOINED; Genomic_DNA.
DR EMBL; AF268364; AAG41140.1; JOINED; Genomic_DNA.
DR EMBL; AF268365; AAG41140.1; JOINED; Genomic_DNA.
DR EMBL; AF268363; AAG41140.1; JOINED; Genomic_DNA.
DR EMBL; AF268366; AAG41141.1; -; Genomic_DNA.
DR EMBL; AF268358; AAG41141.1; JOINED; Genomic_DNA.
DR EMBL; AF268360; AAG41141.1; JOINED; Genomic_DNA.
DR EMBL; AF268361; AAG41141.1; JOINED; Genomic_DNA.
DR EMBL; AF268359; AAG41141.1; JOINED; Genomic_DNA.
DR EMBL; AF268362; AAG41141.1; JOINED; Genomic_DNA.
DR EMBL; AF268364; AAG41141.1; JOINED; Genomic_DNA.
DR EMBL; AF268365; AAG41141.1; JOINED; Genomic_DNA.
DR EMBL; AF268363; AAG41141.1; JOINED; Genomic_DNA.
DR IPI; IPI00700898; -.
DR IPI; IPI00807328; -.
DR RefSeq; NP_776746.1; NM_174321.2.
DR UniGene; Bt.5559; -.
DR ProteinModelPortal; P57695; -.
DR SMR; P57695; 277-337.
DR PRIDE; P57695; -.
DR Ensembl; ENSBTAT00000019143; ENSBTAP00000019143; ENSBTAG00000014395.
DR GeneID; 281783; -.
DR KEGG; bta:281783; -.
DR CTD; 2741; -.
DR eggNOG; NOG265706; -.
DR GeneTree; ENSGT00550000074453; -.
DR HOGENOM; HOG000231336; -.
DR HOVERGEN; HBG051707; -.
DR InParanoid; P57695; -.
DR KO; K05193; -.
DR OMA; KMSRIGF; -.
DR OrthoDB; EOG4TF0KF; -.
DR NextBio; 20805696; -.
DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Compara.
DR GO; GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016934; F:extracellular-glycine-gated chloride channel activity; ISS:UniProtKB.
DR GO; GO:0016594; F:glycine binding; ISS:UniProtKB.
DR GO; GO:0030977; F:taurine binding; ISS:UniProtKB.
DR GO; GO:0022824; F:transmitter-gated ion channel activity; IEA:InterPro.
DR GO; GO:0007340; P:acrosome reaction; IEA:Compara.
DR GO; GO:0007628; P:adult walking behavior; IEA:Compara.
DR GO; GO:0006936; P:muscle contraction; ISS:UniProtKB.
DR GO; GO:0051970; P:negative regulation of transmission of nerve impulse; ISS:UniProtKB.
DR GO; GO:0050884; P:neuromuscular process controlling posture; IEA:Compara.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR GO; GO:2000344; P:positive regulation of acrosome reaction; IEA:Compara.
DR GO; GO:0001508; P:regulation of action potential; IEA:Compara.
DR GO; GO:0060080; P:regulation of inhibitory postsynaptic membrane potential; IEA:Compara.
DR GO; GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IEA:Compara.
DR GO; GO:0060013; P:righting reflex; IEA:Compara.
DR GO; GO:0001964; P:startle response; ISS:UniProtKB.
DR GO; GO:0060012; P:synaptic transmission, glycinergic; IEA:Compara.
DR GO; GO:0007601; P:visual perception; IEA:Compara.
DR Gene3D; G3DSA:2.70.170.10; Neur_chan_lig_bd; 1.
DR InterPro; IPR006028; GABAA_rcpt.
DR InterPro; IPR008127; Glycine_rcpt_A.
DR InterPro; IPR008128; Glycine_rcpt_A1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 2.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR01673; GLYRALPHA.
DR PRINTS; PR01674; GLYRALPHA1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neu_channel_TM; 1.
DR SUPFAM; SSF63712; Neur_chan_LBD; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell junction; Cell membrane; Chloride;
KW Chloride channel; Complete proteome; Disulfide bond; Glycoprotein;
KW Ion transport; Ionic channel; Ligand-gated ion channel; Membrane;
KW Postsynaptic cell membrane; Receptor; Reference proteome; Signal;
KW Synapse; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1 28 By similarity.
FT CHAIN 29 457 Glycine receptor subunit alpha-1.
FT /FTId=PRO_0000000411.
FT TOPO_DOM 29 247 Extracellular (Probable).
FT TRANSMEM 248 274 Helical; (Probable).
FT TRANSMEM 281 298 Helical; (Probable).
FT TRANSMEM 313 336 Helical; (Probable).
FT TOPO_DOM 337 428 Cytoplasmic (Probable).
FT TRANSMEM 429 446 Helical; (Probable).
FT REGION 225 230 Strychnine-binding (By similarity).
FT CARBOHYD 66 66 N-linked (GlcNAc...) (Potential).
FT DISULFID 166 180 By similarity.
FT DISULFID 226 237 By similarity.
FT VAR_SEQ 354 361 Missing (in isoform b).
FT /FTId=VSP_021141.
SQ SEQUENCE 457 AA; 52614 MW; 0C60A814C8ADFDDE CRC64;
MYSFNTLRLY LWETIVFFSL AASKEAEAAR SASKPMSPSD FLDKLMGRTS GYDARIRPNF
KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR LAYNEYPDDS LDLDPSMLDS
IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC
IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA
RFHLERQMGY YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA
SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR HHKSPMLNLF
QEDEAGEGRF NFSAYGMGPA CLQAKDGISV KGANNSNTTN PPPAPSKSPE EMRKLFIQRA
KKIDKISRIG FPMAFLIFNM FYWIIYKIVR REDVHNQ
//