ID GLRA1_BOVIN Reviewed; 457 AA. AC P57695; Q9GKE9; Q9GKF0; DT 08-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 08-DEC-2000, sequence version 1. DT 08-APR-2008, entry version 60. DE Glycine receptor subunit alpha-1 precursor (Glycine receptor 48 kDa DE subunit) (Glycine receptor strychnine-binding subunit). GN Name=GLRA1; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A AND B), AND RP DISEASE. RX MEDLINE=21109390; PubMed=11178872; DOI=10.1006/mcne.2000.0934; RA Pierce K.D., Handford C.A., Morris R., Vafa B., Dennis J.A., RA Healy P.J., Schofield P.R.; RT "A nonsense mutation in the alpha1 subunit of the inhibitory glycine RT receptor associated with bovine myoclonus."; RL Mol. Cell. Neurosci. 17:354-363(2001). CC -!- FUNCTION: The glycine receptor is a neurotransmitter-gated ion CC channel. Binding of glycine to its receptor increases the chloride CC conductance and thus produces hyperpolarization (inhibition of CC neuronal firing) (By similarity). CC -!- SUBUNIT: Pentamer composed of alpha and beta subunits (By CC similarity). CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell CC membrane; Multi-pass membrane protein (By similarity). Cell CC membrane; Multi-pass membrane protein (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=a; CC IsoId=P57695-1; Sequence=Displayed; CC Name=b; CC IsoId=P57695-2; Sequence=VSP_021141; CC -!- DISEASE: Defects in GLRA1 are the cause of inherited congenital CC myoclonus of Poll Hereford calves. It is an autosomal recessive CC disease characterized by hyperesthesia and myoclonic jerks of the CC skeletal musculature that occur both spontaneously and in response CC to sensory stimuli. CC -!- MISCELLANEOUS: The alpha subunit binds strychnine. CC -!- SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF268375; AAG14346.1; -; mRNA. DR EMBL; AF268366; AAG41140.1; -; Genomic_DNA. DR EMBL; AF268358; AAG41140.1; JOINED; Genomic_DNA. DR EMBL; AF268360; AAG41140.1; JOINED; Genomic_DNA. DR EMBL; AF268361; AAG41140.1; JOINED; Genomic_DNA. DR EMBL; AF268359; AAG41140.1; JOINED; Genomic_DNA. DR EMBL; AF268362; AAG41140.1; JOINED; Genomic_DNA. DR EMBL; AF268364; AAG41140.1; JOINED; Genomic_DNA. DR EMBL; AF268365; AAG41140.1; JOINED; Genomic_DNA. DR EMBL; AF268363; AAG41140.1; JOINED; Genomic_DNA. DR EMBL; AF268366; AAG41141.1; -; Genomic_DNA. DR EMBL; AF268358; AAG41141.1; JOINED; Genomic_DNA. DR EMBL; AF268360; AAG41141.1; JOINED; Genomic_DNA. DR EMBL; AF268361; AAG41141.1; JOINED; Genomic_DNA. DR EMBL; AF268359; AAG41141.1; JOINED; Genomic_DNA. DR EMBL; AF268362; AAG41141.1; JOINED; Genomic_DNA. DR EMBL; AF268364; AAG41141.1; JOINED; Genomic_DNA. DR EMBL; AF268365; AAG41141.1; JOINED; Genomic_DNA. DR EMBL; AF268363; AAG41141.1; JOINED; Genomic_DNA. DR RefSeq; NP_776746.1; -. DR UniGene; Bt.5559; -. DR SMR; P57695; 278-337. DR Ensembl; ENSBTAG00000014395; Bos taurus. DR GeneID; 281783; -. DR KEGG; bta:281783; -. DR GO; GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB. DR GO; GO:0016934; F:extracellular-glycine-gated chloride channe...; ISS:UniProtKB. DR GO; GO:0016594; F:glycine binding; ISS:UniProtKB. DR GO; GO:0005515; F:protein binding; ISS:UniProtKB. DR GO; GO:0030977; F:taurine binding; ISS:UniProtKB. DR GO; GO:0006821; P:chloride transport; ISS:UniProtKB. DR GO; GO:0006936; P:muscle contraction; ISS:UniProtKB. DR GO; GO:0051970; P:negative regulation of transmission of nerv...; ISS:UniProtKB. DR GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB. DR GO; GO:0001964; P:startle response; ISS:UniProtKB. DR InterPro; IPR006028; GABAA_rcpt. DR InterPro; IPR008128; Glycine_rcpt_A1. DR InterPro; IPR006029; Neu_channel_TM. DR InterPro; IPR006202; Neur_chan_lig_bd. DR InterPro; IPR006201; Neur_channel. DR Gene3D; G3DSA:2.70.170.10; Neur_chan_lig_bd; 1. DR PANTHER; PTHR18945; Neur_channel; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00253; GABAARECEPTR. DR PRINTS; PR01674; GLYRALPHA1. DR PRINTS; PR00252; NRIONCHANNEL. DR TIGRFAMs; TIGR00860; LIC; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Cell junction; Chloride; Chloride channel; KW Glycoprotein; Ion transport; Ionic channel; Membrane; KW Postsynaptic cell membrane; Receptor; Signal; Synapse; Transmembrane; KW Transport. FT SIGNAL 1 28 By similarity. FT CHAIN 29 457 Glycine receptor subunit alpha-1. FT /FTId=PRO_0000000411. FT TOPO_DOM 29 247 Extracellular (Probable). FT TRANSMEM 248 274 Probable. FT TRANSMEM 281 298 Probable. FT TRANSMEM 313 336 Probable. FT TOPO_DOM 337 428 Cytoplasmic (Probable). FT TRANSMEM 429 446 Probable. FT REGION 225 230 Strychnine-binding (By similarity). FT CARBOHYD 66 66 N-linked (GlcNAc...) (Potential). FT DISULFID 166 180 By similarity. FT DISULFID 226 237 By similarity. FT VAR_SEQ 354 361 Missing (in isoform b). FT /FTId=VSP_021141. SQ SEQUENCE 457 AA; 52614 MW; 0C60A814C8ADFDDE CRC64; MYSFNTLRLY LWETIVFFSL AASKEAEAAR SASKPMSPSD FLDKLMGRTS GYDARIRPNF KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR LAYNEYPDDS LDLDPSMLDS IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA RFHLERQMGY YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR HHKSPMLNLF QEDEAGEGRF NFSAYGMGPA CLQAKDGISV KGANNSNTTN PPPAPSKSPE EMRKLFIQRA KKIDKISRIG FPMAFLIFNM FYWIIYKIVR REDVHNQ //