ID GRA1_BOVIN STANDARD; PRT; 457 AA. AC P57695; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Glycine receptor alpha-1 chain precursor (Glycine receptor 48 kDa DE subunit) (Strychnine binding subunit). GN GLRA1. OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21109390; PubMed=11178872; RA Pierce K.D., Handford C.A., Morris R., Vafa B., Dennis J.A., RA Healy P.J., Schofield P.R.; RT "A nonsense mutation in the alpha1 subunit of the inhibitory glycine RT receptor associated with bovine myoclonus."; RL Mol. Cell. Neurosci. 17:354-363(2001). CC -!- FUNCTION: The glycine receptor is a neurotransmitter-gated ion CC channel. Binding of glycine to its receptor increases the chloride CC conductance and thus produces hyperpolarization (inhibition of CC neuronal firing) (By similarity). CC -!- SUBUNIT: Pentamer composed of alpha (48 kDa) and beta (58 kDa) CC subunits. A third type of subunit (93 kDa) is a peripheral CC membrane protein associated with the cytoplasmic domains of the CC receptor core (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- MISCELLANEOUS: The alpha subunit binds strychnine. CC -!- SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF268375; AAG14346.1; -. DR InterPro; IPR008127; Glycine_recepA. DR InterPro; IPR008128; Glycine_recepA1. DR InterPro; IPR006029; Neu_channel_memb. DR InterPro; IPR006202; Neur_chan_LBD. DR InterPro; IPR006201; Neur_channel. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR01673; GLYRALPHA. DR PRINTS; PR01674; GLYRALPHA1. DR PRINTS; PR00252; NRIONCHANNEL. DR TIGRFAMs; TIGR00860; LIC; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. KW Receptor; Postsynaptic membrane; Ionic channel; Glycoprotein; Signal; KW Transmembrane; Multigene family; Chloride channel. FT SIGNAL 1 28 By similarity. FT CHAIN 29 457 Glycine receptor alpha-1 chain. FT DOMAIN 29 247 Extracellular (Probable). FT TRANSMEM 248 274 Probable. FT TRANSMEM 281 298 Probable. FT TRANSMEM 313 336 Probable. FT DOMAIN 337 428 Cytoplasmic (Probable). FT TRANSMEM 429 446 Probable. FT DISULFID 166 180 By similarity. FT DISULFID 226 237 By similarity. FT CARBOHYD 66 66 N-linked (GlcNAc...) (Potential). FT BINDING 225 225 STRYCHNINE (OR 230) (BY SIMILARITY). FT BINDING 230 230 STRYCHNINE (OR 225) (BY SIMILARITY). SQ SEQUENCE 457 AA; 52613 MW; 0C60A814C8ADFDDE CRC64; MYSFNTLRLY LWETIVFFSL AASKEAEAAR SASKPMSPSD FLDKLMGRTS GYDARIRPNF KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR LAYNEYPDDS LDLDPSMLDS IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA RFHLERQMGY YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR HHKSPMLNLF QEDEAGEGRF NFSAYGMGPA CLQAKDGISV KGANNSNTTN PPPAPSKSPE EMRKLFIQRA KKIDKISRIG FPMAFLIFNM FYWIIYKIVR REDVHNQ //