ID XGPT_BUCAI STANDARD; PRT; 158 AA. AC P57339; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 01-FEB-2005 (Rel. 46, Last annotation update) DE Xanthine phosphoribosyltransferase (EC 2.4.2.22) (Xanthine-guanine DE phosphoribosyltransferase) (XGPRT). GN Name=gpt; OrderedLocusNames=BU251; OS Buchnera aphidicola (subsp. Acyrthosiphon pisum) (Acyrthosiphon pisum OS symbiotic bacterium). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Buchnera. OX NCBI_TaxID=118099; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tokyo 1998; RX MEDLINE=20445173; PubMed=10993077; DOI=10.1038/35024074; RA Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.; RT "Genome sequence of the endocellular bacterial symbiont of aphids RT Buchnera sp. APS."; RL Nature 407:81-86(2000). CC -!- FUNCTION: Acts on guanine, xanthine and to a lesser extent CC hypoxanthine (By similarity). CC -!- CATALYTIC ACTIVITY: 9-(5-phospho-beta-D-ribosyl)xanthine + CC diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. CC -!- COFACTOR: Binds 1 magnesium and 1 sulfate ion per subunit (By CC similarity). CC -!- PATHWAY: Purine salvage. CC -!- SUBUNIT: Homotrimer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity). CC -!- SIMILARITY: Belongs to the purine/pyrimidine CC phosphoribosyltransferase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP001118; BAB12961.1; ALT_INIT. DR HSSP; P00501; 1A98. DR InterPro; IPR002375; Pr/py_rp_transf. DR InterPro; IPR000836; PRtransferase. DR Pfam; PF00156; Pribosyltran; 1. DR PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1. KW Complete proteome; Glycosyltransferase; Magnesium; Metal-binding; KW Purine salvage; Transferase. FT METAL 91 91 Magnesium. FT BINDING 38 38 Sulfate. SQ SEQUENCE 158 AA; 18064 MW; 2B40B2A98EAABF28 CRC64; MSEKYIVTWD MLQIHTRKLA NRLVKKIHSW NGIIAVSRGG LVPSALLARE LGLRCVDTVC IESYNYDCLK ENRKIIKKAE GNGEKIIVID DLVDTGGTAK IIRKLYPKAC FVTIFAKPMG RSLVDNYIID IPQNVWIEQP WDMSISYIPP LIQNYKIK //