ID FOLC_BUCAI STANDARD; PRT; 411 AA. AC P57265; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 13-SEP-2005 (Rel. 48, Last annotation update) DE FolC bifunctional protein [Includes: Folylpolyglutamate synthase DE (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) DE (Tetrahydrofolylpolyglutamate synthase); Dihydrofolate synthase DE (EC 6.3.2.12)]. GN Name=folC; OrderedLocusNames=BU167; OS Buchnera aphidicola (subsp. Acyrthosiphon pisum) (Acyrthosiphon pisum OS symbiotic bacterium). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Buchnera. OX NCBI_TaxID=118099; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tokyo 1998; RX MEDLINE=20445173; PubMed=10993077; DOI=10.1038/35024074; RA Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.; RT "Genome sequence of the endocellular bacterial symbiont of aphids RT Buchnera sp. APS."; RL Nature 407:81-86(2000). CC -!- FUNCTION: Conversion of folates to polyglutamate derivatives. CC -!- CATALYTIC ACTIVITY: ATP + tetrahydrofolyl-[Glu](n) + L-glutamate = CC ADP + phosphate + tetrahydrofolyl-[Glu](n+1). CC -!- CATALYTIC ACTIVITY: ATP + dihydropteroate + L-glutamate = ADP + CC phosphate + dihydrofolate. CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; CC tetrahydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8- CC dihydropteridine diphosphate and 4-aminobenzoate: step 2. CC -!- SIMILARITY: Belongs to the folylpolyglutamate synthase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BA000003; BAB12885.1; -; Genomic_DNA. DR HSSP; P15925; 1FGS. DR InterPro; IPR001645; Fpolygl_synthtse. DR TIGRFAMs; TIGR01499; folC; 1. DR PROSITE; PS01011; FOLYLPOLYGLU_SYNT_1; 1. DR PROSITE; PS01012; FOLYLPOLYGLU_SYNT_2; 1. KW ATP-binding; Complete proteome; Folate biosynthesis; Ligase; KW Multifunctional enzyme; Nucleotide-binding; One-carbon metabolism. FT NP_BIND 50 56 ATP (By similarity). SQ SEQUENCE 411 AA; 46970 MW; 5DDC2DC66539935A CRC64; MINKNYSLSL WLKYLEQLDK KRIYNLTELK FLAKKLGLLK SESFIFTVAG TNGKGTTCAV LERLLLDSGY QVGLYTSPHL INFVERVRIN GFVLHEEEHI DSFQNVELVR NGVLLTYFEF ITLAALILFK RYSLDCIILK VGLGGRLDAT NIIDSDISII TNIGIDHTSI LGRDRISIAR EKCGVFRKNK ISVIGETDIP CSMYQIAKEK KTILKKIDID WSWEKKRNYW NFFHSTIQLY NLPETQVPLS SAATALSTLY YSRFKIKEKI IRKSISNVQL PGRFQVISTF PYIIVDVAHN PNAAFYLSQK IDEINITGKI YAVVGILKDK DILGIIDPLA NKIHHWFTAP LKTIRTATKH ELKKFFPIHN TSILKSIEIA YKKALILVKK EDAIIIFGSF LTVSEFLSLK I //