ID FOLC_BUCAI STANDARD; PRT; 411 AA. AC P57265; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-MAR-2004 (Rel. 43, Last annotation update) DE FolC bifunctional protein [Includes: Folylpolyglutamate synthase DE (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS); DE Dihydrofolate synthase (EC 6.3.2.12)]. GN FOLC OR BU167. OS Buchnera aphidicola (subsp. Acyrthosiphon pisum) (Acyrthosiphon pisum OS symbiotic bacterium). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Buchnera. OX NCBI_TaxID=118099; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Tokyo 1998; RX MEDLINE=20445173; PubMed=10993077; RA Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.; RT "Genome sequence of the endocellular bacterial symbiont of aphids RT Buchnera sp. APS."; RL Nature 407:81-86(2000). CC -!- FUNCTION: Conversion of folates to polyglutamate derivatives. CC -!- CATALYTIC ACTIVITY: ATP + {tetrahydrofolyl-[Glu]}(N) + L-glutamate CC = ADP + phosphate + {tetrahydrofolyl-[Glu]}(N+1). CC -!- CATALYTIC ACTIVITY: ATP + dihydropterate + L-glutamate = ADP + CC phosphate + dihydrofolate. CC -!- PATHWAY: Folate biosynthesis. CC -!- SIMILARITY: Belongs to the folylpolyglutamate synthase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP001118; BAB12885.1; -. DR HSSP; P15925; 1FGS. DR InterPro; IPR001645; Fpolygl_synthtse. DR InterPro; IPR000713; Mur_ligase. DR Pfam; PF01225; Mur_ligase; 1. DR TIGRFAMs; TIGR01499; folC; 1. DR PROSITE; PS01011; FOLYLPOLYGLU_SYNT_1; 1. DR PROSITE; PS01012; FOLYLPOLYGLU_SYNT_2; FALSE_NEG. KW Multifunctional enzyme; Ligase; One-carbon metabolism; ATP-binding; KW Folate biosynthesis; Complete proteome. FT NP_BIND 50 56 ATP (By similarity). SQ SEQUENCE 411 AA; 46970 MW; 5DDC2DC66539935A CRC64; MINKNYSLSL WLKYLEQLDK KRIYNLTELK FLAKKLGLLK SESFIFTVAG TNGKGTTCAV LERLLLDSGY QVGLYTSPHL INFVERVRIN GFVLHEEEHI DSFQNVELVR NGVLLTYFEF ITLAALILFK RYSLDCIILK VGLGGRLDAT NIIDSDISII TNIGIDHTSI LGRDRISIAR EKCGVFRKNK ISVIGETDIP CSMYQIAKEK KTILKKIDID WSWEKKRNYW NFFHSTIQLY NLPETQVPLS SAATALSTLY YSRFKIKEKI IRKSISNVQL PGRFQVISTF PYIIVDVAHN PNAAFYLSQK IDEINITGKI YAVVGILKDK DILGIIDPLA NKIHHWFTAP LKTIRTATKH ELKKFFPIHN TSILKSIEIA YKKALILVKK EDAIIIFGSF LTVSEFLSLK I //