ID CLDI_MOUSE STANDARD; PRT; 264 AA. AC P56857; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 01-MAR-2002 (Rel. 41, Last annotation update) DE Claudin-18. GN CLDN18. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21470315; PubMed=11585919; RA Niimi T., Nagashima K., Ward J.M., Minoo P., Zimonjic D.B., RA Popescu N.C., Kimura S.; RT "claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 RT homeodomain transcription factor, encodes lung- and stomach-specific RT isoforms through alternative splicing."; RL Mol. Cell. Biol. 21:7380-7390(2001). CC -!- FUNCTION: COMPONENT OF TIGHT JUNCTION (TJ) STRANDS. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO THE CLAUDIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF221068; AAF26447.1; -. DR MGD; MGI:1929209; Cldn18. DR InterPro; IPR004031; PMP22_Claudin. DR Pfam; PF00822; PMP22_Claudin; 1. DR PROSITE; PS01346; CLAUDIN; 1. KW Tight junction; Transmembrane. FT TRANSMEM 7 27 POTENTIAL. FT TRANSMEM 81 101 POTENTIAL. FT TRANSMEM 123 143 POTENTIAL. FT TRANSMEM 177 197 POTENTIAL. SQ SEQUENCE 264 AA; 28122 MW; 3CA0D441C4705653 CRC64; MATTTCQVVG LLLSLLGLAG CIAATGMDMW STQDLYDNPV TAVFQYEGLW RSCVQQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG VIGILVSIFA LKCIRIGSMD DSAKAKMTLT SGILFIISGI CAIIGVSVFA NMLVTNFWMS TANMYSGMGG MGGMVQTVQT RYTFGAALFV GWVAGGLTLI GGVMMCIACR GLTPDDSNFK AVSYHASGQN VAYRPGGFKA STGFGSNTRN KKIYDGGART EDDEQSHPTK YDYV //