ID CLD18_MOUSE Reviewed; 264 AA. AC P56857; Q91ZY9; Q91ZZ0; Q91ZZ1; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 30-MAY-2000, sequence version 1. DT 30-NOV-2010, entry version 78. DE RecName: Full=Claudin-18; GN Name=Cldn18; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING. RX MEDLINE=21470315; PubMed=11585919; RX DOI=10.1128/MCB.21.21.7380-7390.2001; RA Niimi T., Nagashima K., Ward J.M., Minoo P., Zimonjic D.B., RA Popescu N.C., Kimura S.; RT "Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 RT homeodomain transcription factor, encodes lung- and stomach-specific RT isoforms through alternative splicing."; RL Mol. Cell. Biol. 21:7380-7390(2001). RN [2] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-250; SER-256 AND RP THR-259, AND MASS SPECTROMETRY. RC TISSUE=Liver; RX PubMed=17203969; DOI=10.1021/pr0604155; RA Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; RT "Protein phosphorylation and expression profiling by Yin-yang RT multidimensional liquid chromatography (Yin-yang MDLC) mass RT spectrometry."; RL J. Proteome Res. 6:250-262(2007). CC -!- FUNCTION: Plays a major role in tight junction-specific CC obliteration of the intercellular space, through calcium- CC independent cell-adhesion activity (By similarity). CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction. Cell CC membrane; Multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=A1.1; CC IsoId=P56857-1; Sequence=Displayed; CC Name=A1.2; CC IsoId=P56857-2; Sequence=VSP_001104, VSP_001105; CC Name=A2.1; CC IsoId=P56857-3; Sequence=VSP_001103; CC Name=A2.2; CC IsoId=P56857-4; Sequence=VSP_001103, VSP_001104, VSP_001105; CC -!- SIMILARITY: Belongs to the claudin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF221068; AAF26447.1; -; mRNA. DR EMBL; AF349450; AAL15635.1; -; mRNA. DR EMBL; AF349451; AAL15636.1; -; mRNA. DR EMBL; AF349453; AAL15638.1; -; mRNA. DR IPI; IPI00116181; -. DR IPI; IPI00227816; -. DR IPI; IPI00227817; -. DR IPI; IPI00227818; -. DR RefSeq; NP_001181850.1; NM_001194921.1. DR RefSeq; NP_001181851.1; NM_001194922.1. DR RefSeq; NP_001181852.1; NM_001194923.1. DR RefSeq; NP_062789.1; NM_019815.3. DR UniGene; Mm.386784; -. DR DIP; DIP-48956N; -. DR STRING; P56857; -. DR TCDB; 8.A.16.4.1; Ca+ channel auxiliary subunit gamma1-gamma8 (CCAgamma) family. DR PhosphoSite; P56857; -. DR PRIDE; P56857; -. DR Ensembl; ENSMUST00000035048; ENSMUSP00000035048; ENSMUSG00000032473. DR Ensembl; ENSMUST00000112882; ENSMUSP00000108503; ENSMUSG00000032473. DR GeneID; 56492; -. DR KEGG; mmu:56492; -. DR UCSC; uc009rep.1; mouse. DR UCSC; uc009req.1; mouse. DR UCSC; uc009rer.1; mouse. DR UCSC; uc009res.1; mouse. DR CTD; 56492; -. DR MGI; MGI:1929209; Cldn18. DR eggNOG; roNOG09605; -. DR HOGENOM; HBG716859; -. DR HOVERGEN; HBG102991; -. DR InParanoid; P56857; -. DR OMA; VQSHPSK; -. DR OrthoDB; EOG9BGCFP; -. DR NextBio; 312778; -. DR ArrayExpress; P56857; -. DR Bgee; P56857; -. DR CleanEx; MM_CLDN18; -. DR Genevestigator; P56857; -. DR GermOnline; ENSMUSG00000032473; Mus musculus. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005923; C:tight junction; ISS:UniProtKB. DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0016338; P:calcium-independent cell-cell adhesion; ISS:UniProtKB. DR InterPro; IPR006187; Claudin. DR InterPro; IPR003928; Claudin18. DR InterPro; IPR017974; Claudin_CS. DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin. DR PANTHER; PTHR12002; Claudin; 1. DR PANTHER; PTHR12002:SF9; Claudin18; 1. DR Pfam; PF00822; PMP22_Claudin; 1. DR PRINTS; PR01077; CLAUDIN. DR PRINTS; PR01448; CLAUDIN18. DR PROSITE; PS01346; CLAUDIN; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell junction; Cell membrane; Membrane; KW Phosphoprotein; Tight junction; Transmembrane; Transmembrane helix. FT CHAIN 1 264 Claudin-18. FT /FTId=PRO_0000144780. FT TOPO_DOM 1 6 Cytoplasmic (Potential). FT TRANSMEM 7 27 Helical; (Potential). FT TOPO_DOM 28 80 Extracellular (Potential). FT TRANSMEM 81 101 Helical; (Potential). FT TOPO_DOM 102 122 Cytoplasmic (Potential). FT TRANSMEM 123 143 Helical; (Potential). FT TOPO_DOM 144 176 Extracellular (Potential). FT TRANSMEM 177 197 Helical; (Potential). FT TOPO_DOM 198 264 Cytoplasmic (Potential). FT MOD_RES 250 250 Phosphothreonine. FT MOD_RES 256 256 Phosphoserine. FT MOD_RES 259 259 Phosphothreonine. FT VAR_SEQ 1 69 MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVT FT AVFQYEGLWRSCVQQSSGFTECRPYFTI -> MSVTACQGL FT GFVVSLIGFAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLW FT RSCVRESSGFTECRGYFTL (in isoform A2.1 and FT isoform A2.2). FT /FTId=VSP_001103. FT VAR_SEQ 208 208 N -> K (in isoform A1.2 and isoform FT A2.2). FT /FTId=VSP_001104. FT VAR_SEQ 209 264 Missing (in isoform A1.2 and isoform FT A2.2). FT /FTId=VSP_001105. SQ SEQUENCE 264 AA; 28122 MW; 3CA0D441C4705653 CRC64; MATTTCQVVG LLLSLLGLAG CIAATGMDMW STQDLYDNPV TAVFQYEGLW RSCVQQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG VIGILVSIFA LKCIRIGSMD DSAKAKMTLT SGILFIISGI CAIIGVSVFA NMLVTNFWMS TANMYSGMGG MGGMVQTVQT RYTFGAALFV GWVAGGLTLI GGVMMCIACR GLTPDDSNFK AVSYHASGQN VAYRPGGFKA STGFGSNTRN KKIYDGGART EDDEQSHPTK YDYV //