ID CLD18_MOUSE STANDARD; PRT; 264 AA. AC P56857; Q91ZY9; Q91ZZ0; Q91ZZ1; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 10-MAY-2005 (Rel. 47, Last annotation update) DE Claudin-18. GN Name=Cldn18; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE, AND ALTERNATIVE SPLICING. RX MEDLINE=21470315; PubMed=11585919; RX DOI=10.1128/MCB.21.21.7380-7390.2001; RA Niimi T., Nagashima K., Ward J.M., Minoo P., Zimonjic D.B., RA Popescu N.C., Kimura S.; RT "Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 RT homeodomain transcription factor, encodes lung- and stomach-specific RT isoforms through alternative splicing."; RL Mol. Cell. Biol. 21:7380-7390(2001). CC -!- FUNCTION: Plays a major role in tight junction-specific CC obliteration of the intercellular space, through calcium- CC independent cell-adhesion activity (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. Tight junctions. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=A1.1; CC IsoId=P56857-1; Sequence=Displayed; CC Name=A1.2; CC IsoId=P56857-2; Sequence=VSP_001104, VSP_001105; CC Name=A2.1; CC IsoId=P56857-3; Sequence=VSP_001103; CC Name=A2.2; CC IsoId=P56857-4; Sequence=VSP_001103, VSP_001104, VSP_001105; CC -!- SIMILARITY: Belongs to the claudin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF221068; AAF26447.1; -; mRNA. DR EMBL; AF349450; AAL15635.1; -; mRNA. DR EMBL; AF349451; AAL15636.1; -; mRNA. DR EMBL; AF349453; AAL15638.1; -; mRNA. DR Ensembl; ENSMUSG00000032473; Mus musculus. DR MGI; MGI:1929209; Cldn18. DR GO; GO:0005615; C:extracellular space; TAS. DR GO; GO:0016021; C:integral to membrane; ISS. DR GO; GO:0005923; C:tight junction; ISS. DR GO; GO:0042802; F:protein self binding; ISS. DR GO; GO:0016338; P:calcium-independent cell-cell adhesion; ISS. DR InterPro; IPR006187; Claudin. DR InterPro; IPR003928; Claudin18. DR InterPro; IPR004031; PMP22_Claudin. DR PANTHER; PTHR12002; Claudin; 1. DR Pfam; PF00822; PMP22_Claudin; 1. DR PRINTS; PR01077; CLAUDIN. DR PRINTS; PR01448; CLAUDIN18. DR PROSITE; PS01346; CLAUDIN; 1. KW Alternative splicing; Tight junction; Transmembrane. FT TOPO_DOM 1 6 Cytoplasmic (Potential). FT TRANSMEM 7 27 Potential. FT TOPO_DOM 28 80 Extracellular (Potential). FT TRANSMEM 81 101 Potential. FT TOPO_DOM 102 122 Cytoplasmic (Potential). FT TRANSMEM 123 143 Potential. FT TOPO_DOM 144 176 Extracellular (Potential). FT TRANSMEM 177 197 Potential. FT TOPO_DOM 198 264 Cytoplasmic (Potential). FT VARSPLIC 1 69 MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVT FT AVFQYEGLWRSCVQQSSGFTECRPYFTI -> MSVTACQGL FT GFVVSLIGFAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLW FT RSCVRESSGFTECRGYFTL (in isoform A2.1 and FT isoform A2.2). FT /FTId=VSP_001103. FT VARSPLIC 208 208 N -> K (in isoform A1.2 and isoform FT A2.2). FT /FTId=VSP_001104. FT VARSPLIC 209 264 Missing (in isoform A1.2 and isoform FT A2.2). FT /FTId=VSP_001105. SQ SEQUENCE 264 AA; 28122 MW; 3CA0D441C4705653 CRC64; MATTTCQVVG LLLSLLGLAG CIAATGMDMW STQDLYDNPV TAVFQYEGLW RSCVQQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG VIGILVSIFA LKCIRIGSMD DSAKAKMTLT SGILFIISGI CAIIGVSVFA NMLVTNFWMS TANMYSGMGG MGGMVQTVQT RYTFGAALFV GWVAGGLTLI GGVMMCIACR GLTPDDSNFK AVSYHASGQN VAYRPGGFKA STGFGSNTRN KKIYDGGART EDDEQSHPTK YDYV //