ID CLD18_MOUSE STANDARD; PRT; 264 AA. AC P56857; Q91ZY9; Q91ZZ0; Q91ZZ1; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 01-MAY-2005 (Rel. 47, Last annotation update) DE Claudin-18. GN Name=Cldn18; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE, AND ALTERNATIVE SPLICING. RX MEDLINE=21470315; PubMed=11585919; RX DOI=10.1128/MCB.21.21.7380-7390.2001; RA Niimi T., Nagashima K., Ward J.M., Minoo P., Zimonjic D.B., RA Popescu N.C., Kimura S.; RT "Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 RT homeodomain transcription factor, encodes lung- and stomach-specific RT isoforms through alternative splicing."; RL Mol. Cell. Biol. 21:7380-7390(2001). CC -!- FUNCTION: Plays a major role in tight junction-specific CC obliteration of the intercellular space, through calcium- CC independent cell-adhesion activity (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. Tight junctions. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=A1.1; CC IsoId=P56857-1; Sequence=Displayed; CC Name=A1.2; CC IsoId=P56857-2; Sequence=VSP_001104, VSP_001105; CC Name=A2.1; CC IsoId=P56857-3; Sequence=VSP_001103; CC Name=A2.2; CC IsoId=P56857-4; Sequence=VSP_001103, VSP_001104, VSP_001105; CC -!- SIMILARITY: Belongs to the claudin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF221068; AAF26447.1; -. DR EMBL; AF349450; AAL15635.1; -. DR EMBL; AF349451; AAL15636.1; -. DR EMBL; AF349453; AAL15638.1; -. DR Ensembl; ENSMUSG00000032473; Mus musculus. DR MGI; MGI:1929209; Cldn18. DR GO; GO:0005615; C:extracellular space; TAS. DR GO; GO:0016021; C:integral to membrane; ISS. DR GO; GO:0005923; C:tight junction; ISS. DR GO; GO:0042802; F:protein self binding; ISS. DR GO; GO:0016338; P:calcium-independent cell-cell adhesion; ISS. DR InterPro; IPR006187; Claudin. DR InterPro; IPR006188; Claudin_reg. DR InterPro; IPR004031; PMP22_Claudin. DR Pfam; PF00822; PMP22_Claudin; 1. DR PRINTS; PR01077; CLAUDIN. DR PRINTS; PR01448; CLAUDIN18. DR PROSITE; PS01346; CLAUDIN; 1. KW Alternative splicing; Tight junction; Transmembrane. FT DOMAIN 1 6 Cytoplasmic (Potential). FT TRANSMEM 7 27 Potential. FT DOMAIN 28 80 Extracellular (Potential). FT TRANSMEM 81 101 Potential. FT DOMAIN 102 122 Cytoplasmic (Potential). FT TRANSMEM 123 143 Potential. FT DOMAIN 144 176 Extracellular (Potential). FT TRANSMEM 177 197 Potential. FT DOMAIN 198 264 Cytoplasmic (Potential). FT VARSPLIC 1 69 MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVT FT AVFQYEGLWRSCVQQSSGFTECRPYFTI -> MSVTACQGL FT GFVVSLIGFAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLW FT RSCVRESSGFTECRGYFTL (in isoform A2.1 and FT isoform A2.2). FT /FTId=VSP_001103. FT VARSPLIC 208 208 N -> K (in isoform A1.2 and isoform FT A2.2). FT /FTId=VSP_001104. FT VARSPLIC 209 264 Missing (in isoform A1.2 and isoform FT A2.2). FT /FTId=VSP_001105. SQ SEQUENCE 264 AA; 28122 MW; 3CA0D441C4705653 CRC64; MATTTCQVVG LLLSLLGLAG CIAATGMDMW STQDLYDNPV TAVFQYEGLW RSCVQQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG VIGILVSIFA LKCIRIGSMD DSAKAKMTLT SGILFIISGI CAIIGVSVFA NMLVTNFWMS TANMYSGMGG MGGMVQTVQT RYTFGAALFV GWVAGGLTLI GGVMMCIACR GLTPDDSNFK AVSYHASGQN VAYRPGGFKA STGFGSNTRN KKIYDGGART EDDEQSHPTK YDYV //