ID CLD18_MOUSE Reviewed; 264 AA. AC P56857; Q91ZY9; Q91ZZ0; Q91ZZ1; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 30-MAY-2000, sequence version 1. DT 12-SEP-2018, entry version 125. DE RecName: Full=Claudin-18; GN Name=Cldn18; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING. RX PubMed=11585919; DOI=10.1128/MCB.21.21.7380-7390.2001; RA Niimi T., Nagashima K., Ward J.M., Minoo P., Zimonjic D.B., RA Popescu N.C., Kimura S.; RT "Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 RT homeodomain transcription factor, encodes lung- and stomach-specific RT isoforms through alternative splicing."; RL Mol. Cell. Biol. 21:7380-7390(2001). RN [2] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Lung; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Plays a major role in tight junction-specific CC obliteration of the intercellular space, through calcium- CC independent cell-adhesion activity. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction. Cell CC membrane; Multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=A1.1; CC IsoId=P56857-1; Sequence=Displayed; CC Name=A1.2; CC IsoId=P56857-2; Sequence=VSP_001104, VSP_001105; CC Name=A2.1; CC IsoId=P56857-3; Sequence=VSP_001103; CC Name=A2.2; CC IsoId=P56857-4; Sequence=VSP_001103, VSP_001104, VSP_001105; CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF221068; AAF26447.1; -; mRNA. DR EMBL; AF349450; AAL15635.1; -; mRNA. DR EMBL; AF349451; AAL15636.1; -; mRNA. DR EMBL; AF349453; AAL15638.1; -; mRNA. DR CCDS; CCDS23437.1; -. [P56857-1] DR CCDS; CCDS57692.1; -. [P56857-2] DR CCDS; CCDS57693.1; -. [P56857-4] DR CCDS; CCDS57694.1; -. [P56857-3] DR RefSeq; NP_001181850.1; NM_001194921.1. [P56857-3] DR RefSeq; NP_001181851.1; NM_001194922.1. [P56857-2] DR RefSeq; NP_001181852.1; NM_001194923.1. [P56857-4] DR RefSeq; NP_062789.1; NM_019815.3. [P56857-1] DR UniGene; Mm.386784; -. DR ProteinModelPortal; P56857; -. DR DIP; DIP-48956N; -. DR IntAct; P56857; 3. DR MINT; P56857; -. DR STRING; 10090.ENSMUSP00000035048; -. DR TCDB; 1.H.1.1.8; the claudin tight junction (claudin1) family. DR iPTMnet; P56857; -. DR PhosphoSitePlus; P56857; -. DR MaxQB; P56857; -. DR PaxDb; P56857; -. DR PRIDE; P56857; -. DR DNASU; 56492; -. DR Ensembl; ENSMUST00000035048; ENSMUSP00000035048; ENSMUSG00000032473. [P56857-1] DR Ensembl; ENSMUST00000112882; ENSMUSP00000108503; ENSMUSG00000032473. [P56857-3] DR Ensembl; ENSMUST00000131922; ENSMUSP00000117382; ENSMUSG00000032473. [P56857-4] DR Ensembl; ENSMUST00000136429; ENSMUSP00000115782; ENSMUSG00000032473. [P56857-2] DR GeneID; 56492; -. DR KEGG; mmu:56492; -. DR UCSC; uc009rep.2; mouse. [P56857-1] DR UCSC; uc009req.2; mouse. [P56857-2] DR UCSC; uc009rer.2; mouse. [P56857-4] DR UCSC; uc009res.2; mouse. [P56857-3] DR CTD; 51208; -. DR MGI; MGI:1929209; Cldn18. DR eggNOG; ENOG410IG28; Eukaryota. DR eggNOG; ENOG410XPD1; LUCA. DR GeneTree; ENSGT00760000119222; -. DR HOGENOM; HOG000220937; -. DR HOVERGEN; HBG102991; -. DR InParanoid; P56857; -. DR KO; K06087; -. DR OMA; VQSHPSK; -. DR OrthoDB; EOG091G0MX2; -. DR PhylomeDB; P56857; -. DR TreeFam; TF331936; -. DR PRO; PR:P56857; -. DR Proteomes; UP000000589; Chromosome 9. DR Bgee; ENSMUSG00000032473; Expressed in 37 organ(s), highest expression level in lung. DR CleanEx; MM_CLDN18; -. DR Genevisible; P56857; MM. DR GO; GO:0005923; C:bicellular tight junction; ISS:UniProtKB. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB. DR GO; GO:0048565; P:digestive tract development; IMP:MGI. DR GO; GO:0045779; P:negative regulation of bone resorption; IDA:MGI. DR GO; GO:2001205; P:negative regulation of osteoclast development; IDA:MGI. DR GO; GO:1900181; P:negative regulation of protein localization to nucleus; IDA:MGI. DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl. DR GO; GO:0071847; P:TNFSF11-mediated signaling pathway; IMP:MGI. DR InterPro; IPR006187; Claudin. DR InterPro; IPR003928; Claudin18. DR InterPro; IPR017974; Claudin_CS. DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin. DR PANTHER; PTHR12002; PTHR12002; 1. DR PANTHER; PTHR12002:SF9; PTHR12002:SF9; 1. DR Pfam; PF00822; PMP22_Claudin; 1. DR PRINTS; PR01448; CLAUDIN18. DR PROSITE; PS01346; CLAUDIN; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell junction; Cell membrane; Complete proteome; KW Membrane; Phosphoprotein; Reference proteome; Tight junction; KW Transmembrane; Transmembrane helix. FT CHAIN 1 264 Claudin-18. FT /FTId=PRO_0000144780. FT TOPO_DOM 1 6 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 7 27 Helical. {ECO:0000255}. FT TOPO_DOM 28 80 Extracellular. {ECO:0000255}. FT TRANSMEM 81 101 Helical. {ECO:0000255}. FT TOPO_DOM 102 122 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 123 143 Helical. {ECO:0000255}. FT TOPO_DOM 144 176 Extracellular. {ECO:0000255}. FT TRANSMEM 177 197 Helical. {ECO:0000255}. FT TOPO_DOM 198 264 Cytoplasmic. {ECO:0000255}. FT MOD_RES 217 217 Phosphoserine. FT {ECO:0000244|PubMed:21183079}. FT VAR_SEQ 1 69 MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVT FT AVFQYEGLWRSCVQQSSGFTECRPYFTI -> MSVTACQGL FT GFVVSLIGFAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLW FT RSCVRESSGFTECRGYFTL (in isoform A2.1 and FT isoform A2.2). {ECO:0000305}. FT /FTId=VSP_001103. FT VAR_SEQ 208 208 N -> K (in isoform A1.2 and isoform FT A2.2). {ECO:0000305}. FT /FTId=VSP_001104. FT VAR_SEQ 209 264 Missing (in isoform A1.2 and isoform FT A2.2). {ECO:0000305}. FT /FTId=VSP_001105. SQ SEQUENCE 264 AA; 28122 MW; 3CA0D441C4705653 CRC64; MATTTCQVVG LLLSLLGLAG CIAATGMDMW STQDLYDNPV TAVFQYEGLW RSCVQQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG VIGILVSIFA LKCIRIGSMD DSAKAKMTLT SGILFIISGI CAIIGVSVFA NMLVTNFWMS TANMYSGMGG MGGMVQTVQT RYTFGAALFV GWVAGGLTLI GGVMMCIACR GLTPDDSNFK AVSYHASGQN VAYRPGGFKA STGFGSNTRN KKIYDGGART EDDEQSHPTK YDYV //