ID CLDI_MOUSE STANDARD; PRT; 264 AA. AC P56857; Q91ZZ1; Q91ZZ0; Q91ZY9; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 15-JUN-2002 (Rel. 41, Last annotation update) DE Claudin-18. GN CLDN18. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A., AND ALTERNATIVE SPLICING. RX MEDLINE=21470315; PubMed=11585919; RA Niimi T., Nagashima K., Ward J.M., Minoo P., Zimonjic D.B., RA Popescu N.C., Kimura S.; RT "claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 RT homeodomain transcription factor, encodes lung- and stomach-specific RT isoforms through alternative splicing."; RL Mol. Cell. Biol. 21:7380-7390(2001). CC -!- FUNCTION: COMPONENT OF TIGHT JUNCTION (TJ) STRANDS. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: 4 isoforms; A1.1 (shown here), A1.2, A2.1 CC and A2.2; are produced by alternative splicing. CC -!- SIMILARITY: BELONGS TO THE CLAUDIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF221068; AAF26447.1; -. DR EMBL; AF349450; AAL15635.1; -. DR EMBL; AF349451; AAL15636.1; -. DR EMBL; AF349453; AAL15638.1; -. DR MGD; MGI:1929209; Cldn18. DR InterPro; IPR001832; Claudin. DR InterPro; IPR004031; PMP22_Claudin. DR Pfam; PF00822; PMP22_Claudin; 1. DR PROSITE; PS01346; CLAUDIN; 1. KW Tight junction; Transmembrane; Alternative splicing. FT TRANSMEM 7 27 POTENTIAL. FT TRANSMEM 81 101 POTENTIAL. FT TRANSMEM 123 143 POTENTIAL. FT TRANSMEM 177 197 POTENTIAL. FT VARSPLIC 1 69 MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVT FT AVFQYEGLWRSCVQQSSGFTECRPYFTI -> MSVTACQGL FT GFVVSLIGFAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLW FT RSCVRESSGFTECRGYFTL (IN ISOFORM A2.1 AND FT ISOFORM A2.2). FT VARSPLIC 208 208 N -> K (IN ISOFORM A1.2 AND ISOFORM FT A2.2). FT VARSPLIC 209 264 MISSING (IN ISOFORM A1.2 AND ISOFORM FT A2.2). SQ SEQUENCE 264 AA; 28122 MW; 3CA0D441C4705653 CRC64; MATTTCQVVG LLLSLLGLAG CIAATGMDMW STQDLYDNPV TAVFQYEGLW RSCVQQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG VIGILVSIFA LKCIRIGSMD DSAKAKMTLT SGILFIISGI CAIIGVSVFA NMLVTNFWMS TANMYSGMGG MGGMVQTVQT RYTFGAALFV GWVAGGLTLI GGVMMCIACR GLTPDDSNFK AVSYHASGQN VAYRPGGFKA STGFGSNTRN KKIYDGGART EDDEQSHPTK YDYV //