ID CXA2_CONMA STANDARD; PRT; 16 AA. AC P56636; DT 15-DEC-1998 (Rel. 37, Created) DT 15-DEC-1998 (Rel. 37, Last sequence update) DT 01-MAR-2002 (Rel. 41, Last annotation update) DE Alpha-conotoxin MII (M2). OS Conus magus (Magus cone). OC Eukaryota; Metazoa; Mollusca; Gastropoda; Caenogastropoda; OC Neogastropoda; Conoidea; Conidae; Conus. OX NCBI_TaxID=6492; RN [1] RP SEQUENCE, AND SYNTHESIS. RC TISSUE=Venom; RX MEDLINE=96205934; PubMed=8631783; RA Cartier G.E., Yoshikami D., Gray W.R., Luo S., Olivera B.M., RA McIntosh J.M.; RT "A new alpha-conotoxin which targets alpha3beta2 nicotinic RT acetylcholine receptors."; RL J. Biol. Chem. 271:7522-7528(1996). RN [2] RP STRUCTURE BY NMR. RX MEDLINE=98062282; PubMed=9398298; RA Shon K.-J., Koerber S.C., Rivier J.E., Olivera B.M., McIntosh J.M.; RT "Three-dimensional solution structure of alpha-conotoxin MII, an RT alpha3beta2 neuronal nicotinic acetylcholine receptor-targeted RT ligand."; RL Biochemistry 36:15693-15700(1997). RN [3] RP STRUCTURE BY NMR. RX MEDLINE=99060038; PubMed=9843366; RA Hill J.M., Oomen C.J., Miranda L.P., Bingham J.-P., Alewood P.F., RA Craik D.J.; RT "Three-dimensional solution structure of alpha-conotoxin MII by NMR RT spectroscopy: effects of solution environment on helicity."; RL Biochemistry 37:15621-15630(1998). CC -!- FUNCTION: ALPHA-CONOTOXINS ACT ON POSTSYNAPTIC MEMBRANES, THEY CC BIND TO THE NICOTINIC ACETYLCHOLINE RECEPTORS (NACHR) AND THUS CC INHIBIT THEM. THIS PEPTIDE BLOCKS MAMMALIAN NICOTINIC CC ACETYLCHOLINE RECEPTORS COMPOSED OF ALPHA-3/BETA-2 SUBUNITS. IT CC HAS AN ACTIVITY 2 TO 4 ORDERS OF MAGNITUDE LESS POTENT ON OTHER CC NACHR SUBUNIT COMBINATIONS. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed by the venom duct. CC -!- SIMILARITY: BELONGS TO THE ALPHA-TYPE CONOTOXIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PDB; 1MII; 21-OCT-98. DR PDB; 1M2C; 13-JAN-99. KW Postsynaptic neurotoxin; Neurotoxin; Toxin; KW Acetylcholine receptor inhibitor; Amidation; 3D-structure. FT DISULFID 2 8 FT DISULFID 3 16 FT MOD_RES 16 16 AMIDATION. SQ SEQUENCE 16 AA; 1716 MW; 282AEF190166CAF9 CRC64; GCCSNPVCHL EHSNLC //