ID CXA2_CONMA STANDARD; PRT; 16 AA. AC P56636; DT 15-DEC-1998 (Rel. 37, Created) DT 15-DEC-1998 (Rel. 37, Last sequence update) DT 15-JUL-1999 (Rel. 38, Last annotation update) DE ALPHA-CONOTOXIN MII (M2). OS Conus magus (Magus cone). OC Eukaryota; Metazoa; Mollusca; Gastropoda; Prosobranchia; OC Neogastropoda; Conoidea; Conidae; Conus. RN [1] RP SEQUENCE, AND SYNTHESIS. RC TISSUE=VENOM; RX MEDLINE; 96205934. RA CARTIER G.E., YOSHIKAMI D., GRAY W.R., LUO S., OLIVERA B.M., RA MCINTOSH J.M.; RT "A new alpha-conotoxin which targets alpha3beta2 nicotinic RT acetylcholine receptors."; RL J. Biol. Chem. 271:7522-7528(1996). RN [2] RP STRUCTURE BY NMR. RX MEDLINE; 98062282. RA SHON K.J., KOERBER S.C., RIVIER J.E., OLIVERA B.M., MCINTOSH J.M.; RT "Three-dimensional solution structure of alpha-conotoxin MII, an RT alpha3beta2 neuronal nicotinic acetylcholine receptor-targeted RT ligand."; RL Biochemistry 36:15693-15700(1997). RN [3] RP STRUCTURE BY NMR. RX MEDLINE; 99060038. RA HILL J.M., OOMEN C.J., MIRANDA L.P., BINGHAM J.-P., ALEWOOD P.F., RA CRAIK D.J.; RT "Three-dimensional solution structure of alpha-conotoxin MII by NMR RT spectroscopy: effects of solution environment on helicity."; RL Biochemistry 37:15621-15630(1998). CC -!- FUNCTION: ALPHA-CONOTOXINS ACT ON POSTSYNAPTIC MEMBRANES, THEY CC BIND TO THE NICOTINIC ACETYLCHOLINE RECEPTORS (NACHR) AND THUS CC INHIBIT THEM. THIS PEPTIDE BLOCKS MAMMALIAN NICOTINIC CC ACETYLCHOLINE RECEPTORS COMPOSED OF ALPHA-3/BETA-2 SUBUNITS. IT CC HAS AN ACTIVITY 2 TO 4 ORDERS OF MAGNITUDE LESS POTENT ON OTHER CC NACHR SUBUNIT COMBINATIONS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PDB; 1MII; 21-OCT-98. DR PDB; 1M2C; 13-JAN-99. KW Postsynaptic neurotoxin; Acetylcholine receptor inhibitor; Amidation; KW Venom; 3D-structure. FT DISULFID 2 8 FT DISULFID 3 16 FT MOD_RES 16 16 AMIDATION. SQ SEQUENCE 16 AA; 1716 MW; 3E440C14 CRC32; GCCSNPVCHL EHSNLC //