ID CD38_MOUSE Reviewed; 304 AA. AC P56528; Q8BFY8; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 23-NOV-2004, sequence version 2. DT 12-JUN-2007, entry version 50. DE ADP-ribosyl cyclase 1 (EC 3.2.2.5) (Cyclic ADP-ribose hydrolase 1) DE (cADPr hydrolase 1) (NIM-R5 antigen) (I-19). GN Name=Cd38; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=B-cell; RX MEDLINE=93389138; PubMed=8376770; RA Harada N., Santos-Argumedo L., Chang R., Grimaldi J.C., Lund F.E., RA Brannan C.I., Copeland N.G., Jenkins N.A., Heath A.W., RA Parkhouse R.M.E., Howard M.; RT "Expression cloning of a cDNA encoding a novel murine B cell RT activation marker. Homology to human CD38."; RL J. Immunol. 151:3111-3118(1993). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Hypothalamus, and Thymus; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Olfactory epithelium; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Synthesizes cyclic ADP-ribose, a second messenger for CC glucose-induced insulin secretion. Also has cADPr hydrolase CC activity (By similarity). CC -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = ADP-ribose + nicotinamide. CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type II membrane CC protein. CC -!- SIMILARITY: Belongs to the ADP-ribosyl cyclase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L11332; AAA03163.1; -; mRNA. DR EMBL; AK038439; BAC30000.1; -; mRNA. DR EMBL; AK040498; BAC30607.1; -; mRNA. DR EMBL; AK042970; BAC31423.1; -; mRNA. DR EMBL; BC046312; AAH46312.1; -; mRNA. DR PIR; I49586; I49586. DR UniGene; Mm.249873; -. DR HSSP; Q10588; 1ISI. DR Ensembl; ENSMUSG00000029084; Mus musculus. DR KEGG; mmu:12494; -. DR MGI; MGI:107474; Cd38. DR ArrayExpress; P56528; -. DR GermOnline; ENSMUSG00000029084; Mus musculus. DR GO; GO:0005624; C:membrane fraction; IDA:MGI. DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IMP:MGI. DR GO; GO:0016849; F:phosphorus-oxygen lyase activity; IMP:MGI. DR InterPro; IPR003193; Rib_hydrolayse. DR PANTHER; PTHR10912; Rib_hydrolayse; 1. DR Pfam; PF02267; Rib_hydrolayse; 1. KW Glycoprotein; Hydrolase; Membrane; NAD; Signal-anchor; Transmembrane. FT CHAIN 1 304 ADP-ribosyl cyclase 1. FT /FTId=PRO_0000144068. FT TOPO_DOM 1 21 Cytoplasmic (Potential). FT TRANSMEM 22 44 Signal-anchor for type II membrane FT protein (Potential). FT TOPO_DOM 45 304 Extracellular (Potential). FT ACT_SITE 123 123 By similarity. FT ACT_SITE 205 205 By similarity. FT CARBOHYD 104 104 N-linked (GlcNAc...) (Potential). FT CARBOHYD 124 124 N-linked (GlcNAc...) (Potential). FT CARBOHYD 213 213 N-linked (GlcNAc...) (Potential). FT CARBOHYD 223 223 N-linked (GlcNAc...) (Potential). FT DISULFID 70 86 By similarity. FT DISULFID 103 184 By similarity. FT DISULFID 164 177 By similarity. FT DISULFID 258 279 By similarity. FT DISULFID 291 300 By similarity. FT CONFLICT 191 191 V -> M (in Ref. 1). FT CONFLICT 229 229 V -> L (in Ref. 1). SQ SEQUENCE 304 AA; 34408 MW; DD0A7747C5F67D6F CRC64; MANYEFSQVS GDRPGCRLSR KAQIGLGVGL LVLIALVVGI VVILLRPRSL LVWTGEPTTK HFSDIFLGRC LIYTQILRPE MRDQNCQEIL STFKGAFVSK NPCNITREDY APLVKLVTQT IPCNKTLFWS KSKHLAHQYT WIQGKMFTLE DTLLGYIADD LRWCGDPSTS DMNYVSCPHW SENCPNNPIT VFWKVISQKF AEDACGVVQV MLNGSLREPF YKNSTFGSVE VFSLDPNKVH KLQAWVMHDI EGASSNACSS SSLNELKMIV QKRNMIFACV DNYRPARFLQ CVKNPEHPSC RLNT //