ID CD38_MOUSE STANDARD; PRT; 304 AA. AC P56528; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE ADP-RIBOSYL CYCLASE 1 (EC 3.2.2.5) (CYCLIC ADP-RIBOSE HYDROLASE 1) DE (CADPR HYDROLASE 1) (NIM-R5 ANTIGEN) (I-19). GN CD38. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=B-CELL; RX MEDLINE; 93389138. RA Harada N., Santos-Argumedo L., Chang R., Grimaldi J.C., Lund F.E., RA Brannan C.I., Copeland N.G., Jenkins N.A., Heath A.W., RA Parkhouse R.M.E., Howard M.; RT "Expression cloning of a cDNA encoding a novel murine B cell RT activation marker. Homology to human CD38."; RL J. Immunol. 151:3111-3118(1993). CC -!- FUNCTION: SYNTHESIZES CYCLIC ADP-RIBOSE, A SECOND MESSENGER FOR CC GLUCOSE-INDUCED INSULIN SECRETION. ALSO HAS CADPR HYDROLASE CC ACTIVITY (BY SIMILARITY). CC -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = NICOTINAMIDE + ADP-RIBOSE. CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. CC -!- SIMILARITY: BELONGS TO THE ADP-RIBOSYL CYCLASE FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L11332; AAA03163.1; -. DR HSSP; P29241; 1LBE. DR MGD; MGI:107474; CD38. KW Hydrolase; NAD; Glycoprotein; Transmembrane; Signal-anchor. FT DOMAIN 1 21 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 22 44 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN). FT DOMAIN 45 304 EXTRACELLULAR (POTENTIAL). FT ACT_SITE 123 123 BY SIMILARITY. FT ACT_SITE 205 205 BY SIMILARITY. FT CARBOHYD 104 104 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 124 124 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 213 213 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 223 223 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 304 AA; 34454 MW; 4761774B2B046191 CRC64; MANYEFSQVS GDRPGCRLSR KAQIGLGVGL LVLIALVVGI VVILLRPRSL LVWTGEPTTK HFSDIFLGRC LIYTQILRPE MRDQNCQEIL STFKGAFVSK NPCNITREDY APLVKLVTQT IPCNKTLFWS KSKHLAHQYT WIQGKMFTLE DTLLGYIADD LRWCGDPSTS DMNYVSCPHW SENCPNNPIT MFWKVISQKF AEDACGVVQV MLNGSLREPF YKNSTFGSLE VFSLDPNKVH KLQAWVMHDI EGASSNACSS SSLNELKMIV QKRNMIFACV DNYRPARFLQ CVKNPEHPSC RLNT //