ID CD38_MOUSE STANDARD; PRT; 304 AA. AC P56528; DT 15-JUL-1998 (REL. 36, CREATED) DT 15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE ADP-RIBOSYL CYCLASE 1 (EC 3.2.2.5) (CYCLIC ADP-RIBOSE HYDROLASE 1) DE (CADPR HYDROLASE 1) (NIM-R5 ANTIGEN) (I-19). GN CD38. OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=B-CELL; RX MEDLINE; 93389138. RA HARADA N., SANTOS-ARGUMEDO L., CHANG R., GRIMALDI J.C., LUND F.E., RA BRANNAN C.I., COPELAND N.G., JENKINS N.A., HEATH A.W., RA PARKHOUSE R.M.E., HOWARD M.; RL J. IMMUNOL. 151:3111-3118(1993). CC -!- FUNCTION: SYNTHESIZES CYCLIC ADP-RIBOSE, A SECOND MESSENGER FOR CC GLUCOSE-INDUCED INSULIN SECRETION. ALSO HAS CADPR HYDROLASE CC ACTIVITY (BY SIMILARITY). CC -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = NICOTINAMIDE + ADP-RIBOSE. CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. CC -!- SIMILARITY: BELONGS TO THE ADP-RIBOSYL CYCLASE FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L11332; -; NOT_ANNOTATED_CDS. DR MGD; MGI:107474; CD38. KW HYDROLASE; GLYCOPROTEIN; TRANSMEMBRANE; SIGNAL-ANCHOR. FT DOMAIN 1 21 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 22 44 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN). FT DOMAIN 45 304 EXTRACELLULAR (POTENTIAL). FT ACT_SITE 123 123 BY SIMILARITY. FT ACT_SITE 205 205 BY SIMILARITY. FT CARBOHYD 104 104 POTENTIAL. FT CARBOHYD 124 124 POTENTIAL. FT CARBOHYD 213 213 POTENTIAL. FT CARBOHYD 223 223 POTENTIAL. SQ SEQUENCE 304 AA; 34454 MW; 1E6D82DB CRC32; MANYEFSQVS GDRPGCRLSR KAQIGLGVGL LVLIALVVGI VVILLRPRSL LVWTGEPTTK HFSDIFLGRC LIYTQILRPE MRDQNCQEIL STFKGAFVSK NPCNITREDY APLVKLVTQT IPCNKTLFWS KSKHLAHQYT WIQGKMFTLE DTLLGYIADD LRWCGDPSTS DMNYVSCPHW SENCPNNPIT MFWKVISQKF AEDACGVVQV MLNGSLREPF YKNSTFGSLE VFSLDPNKVH KLQAWVMHDI EGASSNACSS SSLNELKMIV QKRNMIFACV DNYRPARFLQ CVKNPEHPSC RLNT //