ID PLM_CANFA STANDARD; PRT; 92 AA. AC P56513; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE PHOSPHOLEMMAN PRECURSOR. GN PLM. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 21-92. RC TISSUE=VENTRICULAR MUSCLE; RX MEDLINE; 91250422. RA Palmer C.J., Scott B.T., Jones L.R.; RT "Purification and complete sequence determination of the major plasma RT membrane substrate for cAMP-dependent protein kinase and protein RT kinase C in myocardium."; RL J. Biol. Chem. 266:11126-11130(1991). CC -!- FUNCTION: INDUCES A HYPERPOLARIZATION-ACTIVATED CHLORIDE CURRENT CC WHEN EXPRESSED IN XENOPUS OOCYTES. MAY HAVE A FUNCTIONAL ROLE IN CC MUSCLE CONTRACTION. CC -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: PRESENT IN HEART, ESOPHAGUS, STOMACH, AORTA, CC SKELETAL MUSCLE, SMOOTH MUSCLE, AND LIVER BUT ABSENT FROM BRAIN CC AND KIDNEY. CC -!- PTM: MAJOR PLASMA MEMBRANE SUBSTRATE FOR CAMP-DEPENDENT PROTEIN CC KINASE (PK-A) AND PROTEIN KINASE C (PK-C) IN SEVERAL DIFFERENT CC TISSUES. PHOSPHORYLATED IN RESPONSE TO INSULIN AND ADRENERGIC CC STIMULATION (BY SIMILARITY). CC -!- SIMILARITY: BELONGS TO THE ATP1G1 / PLM / MAT8 FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M63934; -; NOT_ANNOTATED_CDS. DR INTERPRO; IPR000272; -. DR PFAM; PF02038; ATP1G1_PLM_MAT8; 1. DR PROSITE; PS01310; ATP1G1_PLM_MAT8; 1. KW Transmembrane; Phosphorylation; Signal; Ionic channel; Ion transport. FT SIGNAL 1 20 FT CHAIN 21 92 PHOSPHOLEMMAN. FT DOMAIN 21 35 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 36 56 POTENTIAL. FT DOMAIN 57 92 CYTOPLASMIC (POTENTIAL). FT MOD_RES 83 83 PHOSPHORYLATION (BY PKC AND PKA) (BY FT SIMILARITY). FT MOD_RES 88 88 PHOSPHORYLATION (BY PKA) (BY SIMILARITY). SQ SEQUENCE 92 AA; 10500 MW; 890DE301BF8E740A CRC64; MAPLHHILVL CVGFLTTATA EAPQEHDPFT YDYQSLRIGG LIIAGILFIL GILIVLSRRC RCKFNQQQRT GEPDEEEGTF RSSIRRLSTR RR //