ID PLM_CANFA STANDARD; PRT; 92 AA. AC P56513; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Phospholemman precursor (FXYD domain-containing ion transport DE regulator 1). GN FXYD1 OR PLM. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 21-92. RC TISSUE=Ventricular muscle; RX MEDLINE=91250422; PubMed=1710217; RA Palmer C.J., Scott B.T., Jones L.R.; RT "Purification and complete sequence determination of the major plasma RT membrane substrate for cAMP-dependent protein kinase and protein RT kinase C in myocardium."; RL J. Biol. Chem. 266:11126-11130(1991). CC -!- FUNCTION: Induces a hyperpolarization-activated chloride current CC when expressed in xenopus oocytes. May have a functional role in CC muscle contraction. CC -!- SUBCELLULAR LOCATION: Type I membrane protein. CC -!- TISSUE SPECIFICITY: Present in heart, esophagus, stomach, aorta, CC skeletal muscle, smooth muscle, and liver but absent from brain CC and kidney. CC -!- PTM: Major plasma membrane substrate for camp-dependent protein CC kinase (PK-A) and protein kinase C (PK-C) in several different CC tissues. Phosphorylated in response to insulin and adrenergic CC stimulation (By similarity). CC -!- SIMILARITY: Belongs to the FXYD family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M63934; -; NOT_ANNOTATED_CDS. DR PIR; A40533; A40533. DR InterPro; IPR000272; FXYD. DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1. DR PROSITE; PS01310; FXYD; 1. KW Transmembrane; Phosphorylation; Signal; Ionic channel; KW Chloride channel; Chloride; Ion transport. FT SIGNAL 1 20 FT CHAIN 21 92 PHOSPHOLEMMAN. FT DOMAIN 21 35 Extracellular (Potential). FT TRANSMEM 36 56 Potential. FT DOMAIN 57 92 Cytoplasmic (Potential). FT MOD_RES 83 83 PHOSPHORYLATION (BY PKC AND PKA) (BY FT SIMILARITY). FT MOD_RES 88 88 PHOSPHORYLATION (BY PKA) (BY SIMILARITY). SQ SEQUENCE 92 AA; 10500 MW; 890DE301BF8E740A CRC64; MAPLHHILVL CVGFLTTATA EAPQEHDPFT YDYQSLRIGG LIIAGILFIL GILIVLSRRC RCKFNQQQRT GEPDEEEGTF RSSIRRLSTR RR //