ID PLM_CANFA STANDARD; PRT; 92 AA. AC P56513; DT 15-JUL-1998 (REL. 36, CREATED) DT 15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE PHOSPHOLEMMAN PRECURSOR. GN PLM. OS CANIS FAMILIARIS (DOG). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; CARNIVORA. RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 21-92. RC TISSUE=VENTRICULAR MUSCLE; RX MEDLINE; 91250422. RA PALMER C.J., SCOTT B.T., JONES L.R.; RL J. BIOL. CHEM. 266:11126-11130(1991). CC -!- FUNCTION: INDUCES A HYPERPOLARIZATION-ACTIVATED CHLORIDE CURRENT CC WHEN EXPRESSED IN XENOPUS OOCYTES. MAY HAVE A FUNCTIONAL ROLE IN CC MUSCLE CONTRACTION. CC -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: PRESENT IN HEART, ESOPHAGUS, STOMACH, AORTA, CC SKELETAL MUSCLE, SMOOTH MUSCLE, AND LIVER BUT ABSENT FROM BRAIN CC AND KIDNEY. CC -!- PTM: MAJOR PLASMA MEMBRANE SUBSTRATE FOR CAMP-DEPENDENT PROTEIN CC KINASE (PK-A) AND PROTEIN KINASE C (PK-C) IN SEVERAL DIFFERENT CC TISSUES. PHOSPHORYLATED IN RESPONSE TO INSULIN AND ADRENERGIC CC STIMULATION (BY SIMILARITY). CC -!- SIMILARITY: BELONGS TO THE ATP1G1 / PLM / MAT8 FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M63934; -; NOT_ANNOTATED_CDS. DR PROSITE; PS01310; ATP1G1_PLM_MAT8; 1. KW TRANSMEMBRANE; PHOSPHORYLATION; SIGNAL; IONIC CHANNEL; ION TRANSPORT. FT SIGNAL 1 20 FT CHAIN 21 92 PHOSPHOLEMMAN. FT DOMAIN 21 35 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 36 56 POTENTIAL. FT DOMAIN 57 92 CYTOPLASMIC (POTENTIAL). FT MOD_RES 83 83 PHOSPHORYLATION (BY PKC AND PKA) (BY FT SIMILARITY). FT MOD_RES 88 88 PHOSPHORYLATION (BY PKA) (BY SIMILARITY). SQ SEQUENCE 92 AA; 10500 MW; C3D6AF89 CRC32; MAPLHHILVL CVGFLTTATA EAPQEHDPFT YDYQSLRIGG LIIAGILFIL GILIVLSRRC RCKFNQQQRT GEPDEEEGTF RSSIRRLSTR RR //