ID   NDUV3_HUMAN             Reviewed;         108 AA.
AC   P56181; Q6FGD3; Q9HCR5;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2002, sequence version 2.
DT   21-AUG-2007, entry version 56.
DE   NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
DE   precursor (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 9
DE   kDa subunit) (Complex I-9kD) (CI-9kD) (Renal carcinoma antigen NY-REN-
DE   4).
GN   Name=NDUFV3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=98008938; PubMed=9344673; DOI=10.1006/geno.1997.4930;
RA   de Coo R.F.M., Buddiger P., Smeets H.J.M., van Oost B.A.;
RT   "Molecular cloning and characterization of the human mitochondrial
RT   NADH:oxidoreductase 10-kDa gene (NDUFV3).";
RL   Genomics 45:434-437(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=20408883; PubMed=10950923; DOI=10.1006/geno.2000.6253;
RA   Berry A., Scott H.S., Kudoh J., Talior I., Korostishevsky M.,
RA   Wattenhofer M., Guipponi M., Barras C., Rossier C., Shibuya K.,
RA   Wang J., Kawasaki K., Asakawa S., Minoshima S., Shimizu N.,
RA   Antonarakis S.E., Bonne-Tamir B.;
RT   "Refined localization of autosomal recessive nonsyndromic deafness
RT   DFNB10 locus using 34 novel microsatellite markers, genomic structure,
RT   and exclusion of six known genes in the region.";
RL   Genomics 68:22-29(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA   Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA   Korn B., Zuo D., Hu Y., LaBaer J.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION AS A RENAL CANCER ANTIGEN.
RC   TISSUE=Renal cell carcinoma;
RX   MEDLINE=99438124; PubMed=10508479;
RX   DOI=10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5;
RA   Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H.,
RA   Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T.,
RA   Old L.J.;
RT   "Antigens recognized by autologous antibody in patients with renal-
RT   cell carcinoma.";
RL   Int. J. Cancer 83:456-464(1999).
CC   -!- FUNCTION: Transfer of electrons from NADH to the respiratory
CC       chain. The immediate electron acceptor for the enzyme is believed
CC       to be ubiquinone.
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol.
CC   -!- CATALYTIC ACTIVITY: NADH + acceptor = NAD(+) + reduced acceptor.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits. This is a
CC       component of the flavoprotein-sulfur (FP) fragment of the enzyme.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Matrix side.
CC   -!- SIMILARITY: Belongs to the complex I NDUFV3 subunit family.
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DR   EMBL; X99726; CAB56704.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; X99727; CAB56704.1; JOINED; Genomic_DNA.
DR   EMBL; X99728; CAB56704.1; JOINED; Genomic_DNA.
DR   EMBL; AB038163; BAB13732.1; -; Genomic_DNA.
DR   EMBL; CR542174; CAG46971.1; -; mRNA.
DR   EMBL; CR542190; CAG46987.1; -; mRNA.
DR   EMBL; BC033766; AAH33766.1; -; mRNA.
DR   EMBL; BC054016; AAH54016.1; -; mRNA.
DR   UniGene; Hs.473937; -.
DR   Ensembl; ENSG00000160194; Homo sapiens.
DR   KEGG; hsa:4731; -.
DR   HGNC; HGNC:7719; NDUFV3.
DR   MIM; 602184; gene.
DR   PharmGKB; PA31529; -.
DR   Reactome; REACT_6305.1; Electron Transport Chain.
DR   ArrayExpress; P56181; -.
DR   GermOnline; ENSG00000160194; Homo sapiens.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; NAS:UniProtKB.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to u...; NAS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; NAD; Oxidoreductase; Transit peptide;
KW   Ubiquinone.
FT   TRANSIT       1     34       Mitochondrion (By similarity).
FT   CHAIN        35    108       NADH dehydrogenase [ubiquinone]
FT                                flavoprotein 3.
FT                                /FTId=PRO_0000020025.
FT   CONFLICT      9      9       Q -> K (in Ref. 1).
FT   CONFLICT     57     57       K -> SE (in Ref. 1).
SQ   SEQUENCE   108 AA;  11941 MW;  BD7375474AB0B1EC CRC64;
     MAAPCLLRQG RAGALKTMLQ EAQVFRGLAS TVSLSAESGK SEKGQPQNSK KQSPPKKPAP
     VPAEPFDNTT YKNLQHHDYS TYTFLDLNLE LSKFRMPQPS SGRESPRH
//