ID UCN1_RAT Reviewed; 122 AA. AC P55090; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 16-APR-2014, entry version 98. DE RecName: Full=Urocortin; DE AltName: Full=Corticotensin; DE Flags: Precursor; GN Name=Ucn; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; RX PubMed=7477349; DOI=10.1038/378287a0; RA Vaughan J.M., Donaldson C.J., Bittencourt J., Perrin M.H., Lewis K.A., RA Sutton S.W., Chan R., Turnbull A., Lovejoy D., Rivier C., Rivier J.E., RA Sawchenko P., Vale W.W.; RT "Urocortin, a mammalian neuropeptide related to fish urotensin I and RT to corticotropin-releasing factor."; RL Nature 378:287-292(1995). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Lewis; RA Park J.H., Lee Y.J., Kim K.L.; RT "Detection of rat urocortin in lymphoid tissues: implications for the RT functional assessment of urocortin as a novel neuro-immunomodulatory RT peptide."; RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Acts in vitro to stimulate the secretion of CC adrenocorticotropic hormone (ACTH). Binds with high affinity to CC CRF receptor types 1, 2-alpha, and 2-beta. CC -!- SUBUNIT: Interacts with CRHR1 and CRHR2 (via their N-terminal CC extracellular domain) (By similarity). CC -!- INTERACTION: CC P35353:Crhr1; NbExp=3; IntAct=EBI-9030248, EBI-9030306; CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing CC factor/urotensin I family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U33935; AAA87566.1; -; mRNA. DR EMBL; AF093623; AAF63153.1; -; Genomic_DNA. DR PIR; S60262; S60262. DR RefSeq; NP_062023.1; NM_019150.1. DR UniGene; Rn.10190; -. DR ProteinModelPortal; P55090; -. DR SMR; P55090; 81-120. DR BioGrid; 247834; 4. DR IntAct; P55090; 1. DR STRING; 10116.ENSRNOP00000008037; -. DR PRIDE; P55090; -. DR Ensembl; ENSRNOT00000008037; ENSRNOP00000008037; ENSRNOG00000006090. DR GeneID; 29151; -. DR KEGG; rno:29151; -. DR CTD; 7349; -. DR RGD; 3929; Ucn. DR eggNOG; NOG46022; -. DR GeneTree; ENSGT00510000049284; -. DR HOGENOM; HOG000121779; -. DR HOVERGEN; HBG036241; -. DR InParanoid; P55090; -. DR OMA; LRWSPGA; -. DR OrthoDB; EOG73JKZD; -. DR PhylomeDB; P55090; -. DR TreeFam; TF332956; -. DR NextBio; 608159; -. DR PRO; PR:P55090; -. DR Genevestigator; P55090; -. DR GO; GO:0030424; C:axon; IDA:RGD. DR GO; GO:0043679; C:axon terminus; IDA:RGD. DR GO; GO:0030425; C:dendrite; IDA:RGD. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0043025; C:neuronal cell body; IDA:RGD. DR GO; GO:0043204; C:perikaryon; IDA:RGD. DR GO; GO:0043196; C:varicosity; IDA:RGD. DR GO; GO:0051430; F:corticotropin-releasing hormone receptor 1 binding; IPI:RGD. DR GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IPI:RGD. DR GO; GO:0001664; F:G-protein coupled receptor binding; IDA:RGD. DR GO; GO:0046811; F:histone deacetylase inhibitor activity; IDA:RGD. DR GO; GO:0034199; P:activation of protein kinase A activity; IDA:RGD. DR GO; GO:0009060; P:aerobic respiration; IDA:RGD. DR GO; GO:0008306; P:associative learning; IDA:RGD. DR GO; GO:0042756; P:drinking behavior; IMP:RGD. DR GO; GO:0007631; P:feeding behavior; IMP:RGD. DR GO; GO:0007565; P:female pregnancy; IEP:RGD. DR GO; GO:0035483; P:gastric emptying; IDA:RGD. DR GO; GO:0006954; P:inflammatory response; IEP:RGD. DR GO; GO:0007611; P:learning or memory; IDA:RGD. DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:RGD. DR GO; GO:0032099; P:negative regulation of appetite; IDA:RGD. DR GO; GO:0045776; P:negative regulation of blood pressure; IDA:RGD. DR GO; GO:0060548; P:negative regulation of cell death; IMP:RGD. DR GO; GO:0045792; P:negative regulation of cell size; IDA:RGD. DR GO; GO:2000252; P:negative regulation of feeding behavior; IDA:RGD. DR GO; GO:0060455; P:negative regulation of gastric acid secretion; IDA:RGD. DR GO; GO:0010629; P:negative regulation of gene expression; IDA:RGD. DR GO; GO:0031064; P:negative regulation of histone deacetylation; IDA:GOC. DR GO; GO:0046888; P:negative regulation of hormone secretion; IDA:RGD. DR GO; GO:0060547; P:negative regulation of necrotic cell death; IDA:RGD. DR GO; GO:1901215; P:negative regulation of neuron death; IDA:RGD. DR GO; GO:0031175; P:neuron projection development; IDA:RGD. DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:RGD. DR GO; GO:0030157; P:pancreatic juice secretion; IDA:RGD. DR GO; GO:2000987; P:positive regulation of behavioral fear response; IDA:RGD. DR GO; GO:0090280; P:positive regulation of calcium ion import; IDA:RGD. DR GO; GO:0030819; P:positive regulation of cAMP biosynthetic process; IDA:RGD. DR GO; GO:0060452; P:positive regulation of cardiac muscle contraction; IDA:RGD. DR GO; GO:0030307; P:positive regulation of cell growth; IDA:RGD. DR GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:RGD. DR GO; GO:0051461; P:positive regulation of corticotropin secretion; IDA:RGD. DR GO; GO:0045740; P:positive regulation of DNA replication; IDA:RGD. DR GO; GO:0010628; P:positive regulation of gene expression; IDA:RGD. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IDA:RGD. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:RGD. DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:RGD. DR GO; GO:0045727; P:positive regulation of translation; IDA:RGD. DR GO; GO:0043117; P:positive regulation of vascular permeability; IDA:RGD. DR GO; GO:0045909; P:positive regulation of vasodilation; IDA:RGD. DR GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IDA:RGD. DR GO; GO:0032355; P:response to estradiol; IEP:RGD. DR GO; GO:0051384; P:response to glucocorticoid; IEP:RGD. DR GO; GO:0006979; P:response to oxidative stress; IDA:RGD. DR GO; GO:0048265; P:response to pain; IEP:RGD. DR InterPro; IPR018446; Corticotropin-releasing_fac_CS. DR InterPro; IPR000187; Corticotropin-releasing_factor. DR InterPro; IPR003620; Urocortin_CRF. DR PANTHER; PTHR15035; PTHR15035; 1. DR Pfam; PF00473; CRF; 1. DR PRINTS; PR01612; CRFFAMILY. DR SMART; SM00039; CRF; 1. DR PROSITE; PS00511; CRF; 1. PE 1: Evidence at protein level; KW Amidation; Cleavage on pair of basic residues; Complete proteome; KW Hormone; Reference proteome; Secreted; Signal. FT SIGNAL 1 25 Potential. FT PROPEP 26 80 FT /FTId=PRO_0000006237. FT PEPTIDE 81 120 Urocortin. FT /FTId=PRO_0000006238. FT MOD_RES 120 120 Valine amide (By similarity). SQ SEQUENCE 122 AA; 13711 MW; 9F0AF834CBFFCE74 CRC64; MRQRGRATLL VALLLLVQLR PESSQWSPAA AAANVVQDPN LRWNPGVRNQ GGGVRALLLL LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL ARTQSQRERA EQNRIIFDSV GK //