ID UROC_RAT STANDARD; PRT; 122 AA. AC P55090; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE UROCORTIN PRECURSOR (CORTICOTENSIN). GN UCN. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=SPRAGUE-DAWLEY; RX MEDLINE=96069764; PubMed=7477349; RA Vaughan J.M., Donaldson C.J., Bittencourt J., Perrin M.H., Lewis K.A., RA Sutton S.W., Chan R., Turnbull A., Lovejoy D., Rivier C., Rivier J.E., RA Sawchenko P., Vale W.W.; RT "Urocortin, a mammalian neuropeptide related to fish urotensin I and RT to corticotropin-releasing factor."; RL Nature 378:287-292(1995). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=LEWIS; RA Park J.H., Lee Y.J., Kim K.L.; RT "Detection of rat urocortin in lymphoid tissues: implications for the RT functional assessment of urocortin as a novel neuro-immunomodulatory RT peptide."; RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: ACTS IN VITRO TO STIMULATE THE SECRETION OF CC ADRENOCORTICOTROPIC HORMONE (ACTH). BINDS WITH HIGH AFFINITY TO CC CRF RECEPTOR TYPES 1, 2-ALPHA, AND 2-BETA. CC -!- SIMILARITY: BELONGS TO THE SAUVAGINE/CORTICOTROPIN-RELEASING CC FACTOR/UROTENSIN I FAMILY OF PEPTIDES. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U33935; AAA87566.1; -. DR EMBL; AF093623; AAF63153.1; -. DR InterPro; IPR000187; CRF. DR InterPro; IPR003620; Urocortin_CRF. DR Pfam; PF00473; CRF; 1. DR ProDom; PD005970; -; 1. DR SMART; SM00039; CRF; 1. DR PROSITE; PS00511; CRF; 1. KW Hormone; Amidation; Cleavage on pair of basic residues; Signal. FT SIGNAL 1 25 POTENTIAL. FT PROPEP 26 80 FT PEPTIDE 81 120 UROCORTIN. FT MOD_RES 120 120 AMIDATION (G-121 PROVIDE AMIDE GROUP) (BY FT SIMILARITY). SQ SEQUENCE 122 AA; 13711 MW; 9F0AF834CBFFCE74 CRC64; MRQRGRATLL VALLLLVQLR PESSQWSPAA AAANVVQDPN LRWNPGVRNQ GGGVRALLLL LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL ARTQSQRERA EQNRIIFDSV GK //