ID UCN1_RAT Reviewed; 122 AA. AC P55090; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 12-DEC-2006, entry version 44. DE Urocortin precursor (Corticotensin). GN Name=Ucn; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; RX MEDLINE=96069764; PubMed=7477349; DOI=10.1038/378287a0; RA Vaughan J.M., Donaldson C.J., Bittencourt J., Perrin M.H., Lewis K.A., RA Sutton S.W., Chan R., Turnbull A., Lovejoy D., Rivier C., Rivier J.E., RA Sawchenko P., Vale W.W.; RT "Urocortin, a mammalian neuropeptide related to fish urotensin I and RT to corticotropin-releasing factor."; RL Nature 378:287-292(1995). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Lewis; RA Park J.H., Lee Y.J., Kim K.L.; RT "Detection of rat urocortin in lymphoid tissues: implications for the RT functional assessment of urocortin as a novel neuro-immunomodulatory RT peptide."; RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Acts in vitro to stimulate the secretion of CC adrenocorticotropic hormone (ACTH). Binds with high affinity to CC CRF Receptor types 1, 2-alpha, and 2-beta. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing CC factor/urotensin I family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U33935; AAA87566.1; -; mRNA. DR EMBL; AF093623; AAF63153.1; -; Genomic_DNA. DR PIR; S60262; S60262. DR UniGene; Rn.10190; -. DR GermOnline; ENSRNOG00000006090; Rattus norvegicus. DR Ensembl; ENSRNOG00000006090; Rattus norvegicus. DR RGD; 3929; Ucn. DR ArrayExpress; P55090; -. DR GO; GO:0001664; F:G-protein-coupled receptor binding; IDA:RGD. DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:RGD. DR GO; GO:0006979; P:response to oxidative stress; IDA:RGD. DR InterPro; IPR000187; Corticoliberin. DR InterPro; IPR003620; Urocortin_CRF. DR Pfam; PF00473; CRF; 1. DR PRINTS; PR01612; CRFFAMILY. DR ProDom; PD005970; Urocortin_CRF; 1. DR SMART; SM00039; CRF; 1. DR PROSITE; PS00511; CRF; 1. KW Amidation; Cleavage on pair of basic residues; Hormone; Signal. FT SIGNAL 1 25 Potential. FT PROPEP 26 80 FT /FTId=PRO_0000006237. FT PEPTIDE 81 120 Urocortin. FT /FTId=PRO_0000006238. FT MOD_RES 120 120 Valine amide (G-121 provides amide group) FT (By similarity). SQ SEQUENCE 122 AA; 13711 MW; 9F0AF834CBFFCE74 CRC64; MRQRGRATLL VALLLLVQLR PESSQWSPAA AAANVVQDPN LRWNPGVRNQ GGGVRALLLL LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL ARTQSQRERA EQNRIIFDSV GK //