ID UROC_RAT STANDARD; PRT; 122 AA. AC P55090; DT 01-OCT-1996 (REL. 34, CREATED) DT 01-OCT-1996 (REL. 34, LAST SEQUENCE UPDATE) DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) DE UROCORTIN PRECURSOR (CORTICOTENSIN). GN UCN. OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=SPRAGUE-DAWLEY; RX MEDLINE; 96069764. RA VAUGHAN J.M., DONALDSON C.J., BITTENCOURT J., PERRIN M.H., LEWIS K.A., RA SUTTON S.W., CHAN R., TURNBULL A., LOVEJOY D., RIVIER C., RIVIER J.E., RA SAWCHENKO P., VALE W.W.; RL NATURE 378:287-292(1995). CC -!- FUNCTION: ACTS IN VITRO TO STIMULATE THE SECRETION OF CC ADRENOCORTICOTROPIC HORMONE (ACTH). BINDS WITH HIGH AFFINITY TO CC CRF RECEPTOR TYPES 1, 2-ALPHA, AND 2-BETA. CC -!- SIMILARITY: BELONGS TO THE SAUVAGINE/CORTICOTROPIN-RELEASING CC FACTOR/UROTENSIN I FAMILY OF PEPTIDES. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U33935; G1065909; -. KW HORMONE; AMIDATION; CLEAVAGE ON PAIR OF BASIC RESIDUES; SIGNAL. FT SIGNAL 1 25 POTENTIAL. FT PEPTIDE 81 120 UROCORTIN. FT MOD_RES 120 120 AMIDATION (G-121 PROVIDE AMIDE GROUP) (BY FT SIMILARITY). SQ SEQUENCE 122 AA; 13711 MW; C5FCF826 CRC32; MRQRGRATLL VALLLLVQLR PESSQWSPAA AAANVVQDPN LRWNPGVRNQ GGGVRALLLL LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL ARTQSQRERA EQNRIIFDSV GK //