ID AQP4_HUMAN STANDARD; PRT; 323 AA. AC P55087; P78564; DT 01-OCT-1996 (REL. 34, CREATED) DT 01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE AQUAPORIN 4 (WCH4) (MERCURIAL-INSENSITIVE WATER CHANNEL) (MIWC). GN AQP4. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=FETAL BRAIN; RX MEDLINE; 96032721. RA YANG B., MA T., VERKMAN A.S.; RL J. BIOL. CHEM. 270:22907-22913(1995). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 96176324. RA MISAKA T., ABE K., IWABUCHI K., KUSAKABE Y., ICHINOSE M., MIKI K., RA EMORI Y., ARAI S.; RL FEBS LETT. 381:208-212(1996). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 97008105. RA LU M., LEE M.D., SMITH B.L., JUNG J.S., AGRE P., VERDIJK M.A.J., RA MERKX G., RIJSS J.P.L., DEEN P.M.T.; RL PROC. NATL. ACAD. SCI. U.S.A. 93:10908-10912(1996). CC -!- FUNCTION: FORMS A WATER-SPECIFIC CHANNEL. OSMORECEPTOR WHICH CC REGULATES BODY WATER BALANCE AND MEDIATES WATER FLOW WITHIN THE CC CENTRAL NERVOUS SYSTEM. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: BRAIN - MUSCLE >> HEART, KIDNEY, LUNG, AND CC TRACHEA. CC -!- ALTERNATIVE PRODUCTS: TWO FORMS ARE PRODUCED BY ALTERNATIVE CC SPLICING OF THE SAME GENE. CC -!- SIMILARITY: BELONGS TO THE MIP FAMILY OF TRANSMEMBRANE CHANNEL CC PROTEINS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U34846; G1072055; ALT_INIT. DR EMBL; U34845; G1072053; ALT_INIT. DR EMBL; D63412; G1236246; -. DR EMBL; U63622; G1680708; -. DR EMBL; U63623; G1680710; -. DR MIM; 600308; -. DR PROSITE; PS00221; MIP; 1. KW TRANSPORT; TRANSMEMBRANE; ALTERNATIVE SPLICING. FT DOMAIN 1 36 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 37 57 POTENTIAL. FT DOMAIN 58 64 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 65 85 POTENTIAL. FT DOMAIN 86 115 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 116 136 POTENTIAL. FT DOMAIN 137 155 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 156 176 POTENTIAL. FT DOMAIN 177 184 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 185 205 POTENTIAL. FT DOMAIN 206 231 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 232 252 POTENTIAL. FT DOMAIN 253 323 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 153 153 POTENTIAL. FT CARBOHYD 206 206 POTENTIAL. FT VARSPLIC 1 22 MISSING (IN FORM 1). FT CONFLICT 246 246 G -> A (IN REF. 1). FT CONFLICT 287 288 VE -> AK (IN REF. 1). FT CONFLICT 296 296 P -> L (IN REF. 1). SQ SEQUENCE 323 AA; 34829 MW; FC0A507B CRC32; MSDRPTARRW GKCGPLCTRE NIMVAFKGVW TQAFWKAVTA EFLAMLIFVL LSLGSTINWG GTEKPLPVDM VLISLCFGLS IATMVQCFGH ISGGHINPAV TVAMVCTRKI SIAKSVFYIA AQCLGAIIGA GILYLVTPPS VVGGLGVTMV HGNLTAGHGL LVELIITFQL VFTIFASCDS KRTDVTGSIA LAIGFSVAIG HLFAINYTGA SMNPARSFGP AVIMGNWENH WIYWVGPIIG AVLAGGLYEY VFCPDVEFKR RFKEAFSKAA QQTKGSYMEV EDNRSQVETD DLILKPGVVH VIDVDRGEEK KGKDQSGEVL SSV //