ID AQP4_HUMAN STANDARD; PRT; 341 AA. AC P55087; DT 01-OCT-1996 (REL. 34, CREATED) DT 01-OCT-1996 (REL. 34, LAST SEQUENCE UPDATE) DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) DE AQUAPORIN 4 (WCH4) (MERCURIAL-INSENSITIVE WATER CHANNEL) (MIWC). GN AQP4. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=FETAL BRAIN; RX MEDLINE; 96032721. RA YANG B., MA T., VERKMAN A.S.; RL J. BIOL. CHEM. 270:22907-22913(1995). CC -!- FUNCTION: FORMS A WATER-SPECIFIC CHANNEL. OSMORECEPTOR WHICH CC REGULATES BODY WATER BALANCE AND MEDIATES WATER FLOW WITHIN THE CC CENTRAL NERVOUS SYSTEM. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- ALTERNATIVE PRODUCTS: TWO FORMS ARE PRODUCED BY ALTERNATIVE CC SPLICING OF THE SAME GENE. CC -!- TISSUE SPECIFICITY: BRAIN - MUSCLE >> HEART, KIDNEY, LUNG, AND CC TRACHEA. CC -!- SIMILARITY: BELONGS TO THE MIP FAMILY OF TRANSMEMBRANE CHANNEL CC PROTEINS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U34846; G1072055; -. DR EMBL; U34845; G1072053; -. DR MIM; 600308; -. DR MIM; 600973; -. KW TRANSPORT; TRANSMEMBRANE; ALTERNATIVE SPLICING. FT DOMAIN 1 54 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 55 75 POTENTIAL. FT DOMAIN 76 82 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 83 103 POTENTIAL. FT DOMAIN 104 133 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 134 154 POTENTIAL. FT DOMAIN 155 173 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 174 194 POTENTIAL. FT DOMAIN 195 202 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 203 223 POTENTIAL. FT DOMAIN 224 249 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 250 270 POTENTIAL. FT DOMAIN 271 341 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 171 171 POTENTIAL. FT CARBOHYD 224 224 POTENTIAL. FT VARSPLIC 1 40 MISSING (IN FORM 1). SQ SEQUENCE 341 AA; 36787 MW; 679EAAAA CRC32; MRKNHACFVE TPNLAGEGMS DRPTARRWGK CGPLCTRENI MVAFKGVWTQ AFWKAVTAEF LAMLIFVLLS LGSTINWGGT EKPLPVDMVL ISLCFGLSIA TMVQCFGHIS GGHINPAVTV AMVCTRKISI AKSVFYIAAQ CLGAIIGAGI LYLVTPPSVV GGLGVTMVHG NLTAGHGLLV ELIITFQLVF TIFASCDSKR TDVTGSIALA IGFSVAIGHL FAINYTGASM NPARSFGPAV IMGNWENHWI YWVGPIIGAV LAGALYEYVF CPDVEFKRRF KEAFSKAAQQ TKGSYMEVED NRSQAKTDDL ILKLGVVHVI DVDRGEEKKG KDQSGEVLSS V //