ID HMC2_BLAGE STANDARD; PRT; 455 AA. AC P54870; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 01-OCT-1996 (Rel. 34, Last annotation update) DE HYDROXYMETHYLGLUTARYL-COA SYNTHASE 2 (EC 4.1.3.5) (HMG-COA SYNTHASE 2) DE (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE 2). GN HMGCS-2. OS Blattella germanica (German cockroach). OC Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta; OC Pterygota; Neoptera; Orthopteroidea; Dictyoptera; Blattaria; OC Blaberoidea; Blattellidae; Blattellinae; Blattella. OX NCBI_TaxID=6973; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=94216267; PubMed=7909314; RA Buesa C., Martinez-Gonzalez J., Casals N., Haro D., Piulachs M.D., RA Belles X., Hegardt F.G.; RT "Blattella germanica has two HMG-CoA synthase genes. Both are RT regulated in the ovary during the gonadotrophic cycle."; RL J. Biol. Chem. 269:11707-11713(1994). CC -!- FUNCTION: THIS ENZYME CONDENSES ACETYL-COA WITH ACETOACETYL-COA TO CC FORM HMG-COA, WHICH IS THE SUBSTRATE FOR HMG-COA REDUCTASE (BY CC SIMILARITY). CC -!- CATALYTIC ACTIVITY: (S)-3-HYDROXY-3-METHYLGLUTARYL-COA + COA = CC ACETYL-COA + H(2)O + ACETOACETYL-COA. CC -!- PATHWAY: PRODUCTION OF MEVALONATE FROM HMG-COA PRIOR TO THE CC SYNTHESIS OF STEROLS AND ISOPRENOIDS SUCH AS JUVENILE HORMONES. CC -!- SIMILARITY: BELONGS TO THE HMG-COA SYNTHASE FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X77516; CAA54652.1; -. DR InterPro; IPR000590; -. DR Pfam; PF01154; HMG_CoA_synt; 1. DR PROSITE; PS01226; HMG_COA_SYNTHASE; 1. KW Lyase; Sterol biosynthesis; Multigene family. FT ACT_SITE 120 120 POTENTIAL. SQ SEQUENCE 455 AA; 51425 MW; DD030356548A63B1 CRC64; MAHWPEDVGI IGIEMIFPSL YVDQAELETY DEVSPGKYTM GLGQDKMGVC TDREDINSLC LTAVDKLMER NNIDYNDIGW LEVGTETILD KVKSVKTVLM QLFEESGNTD VEGIDTINAC YRGTAALFNA LIWIESSSWD GRYAIVVAAD IAIYAKECSP TGGAGALLML IGANAPIVID RGVRASHMKH AYDFYKPDLM SEYPVVDGKL SVQCYLSALD HCYPRFCSKT EKYLKRCGKE NTKIDLDYFD AFVFHSPYCK LVQKSVARLV LNDFIQYPEK YQDLQQLRNL KFEDTYFDRD IEKIFMDKSK QLFEKKTKPS LMLANQVGNM YTTSLYGGLV SLLISEDIGE LAGKCICMFS YGSGFAASMF SLHISTDSSP GSTLSRLVTN LTHIKPQVQQ RVKLSPGEFE NIMEIREQNH HKAPYTPVAS PNTLFPGTWY LESIDSMHRR KYKRV //