ID   LIP1_HUMAN     STANDARD;      PRT;   467 AA.
AC   P54315;
DT   01-OCT-1996 (Rel. 34, Created)
DT   01-OCT-1996 (Rel. 34, Last sequence update)
DT   30-MAY-2000 (Rel. 39, Last annotation update)
DE   PANCREATIC LIPASE RELATED PROTEIN 1 PRECURSOR (EC 3.1.1.3).
GN   PNLIPRP1 OR PLRP1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=PANCREAS;
RX   MEDLINE=92355622; PubMed=1379598;
RA   Giller T., Buchwald P., Blum-Kaelin D., Hunziker W.;
RT   "Two novel human pancreatic lipase related proteins, hPLRP1 and
RT   hPLRP2. Differences in colipase dependence and in lipase activity.";
RL   J. Biol. Chem. 267:16509-16516(1992).
CC   -!- CATALYTIC ACTIVITY: TRIACYLGLYCEROL + H(2)O = DIACYLGLYCEROL +
CC       A FATTY ACID ANION.
CC   -!- SUBCELLULAR LOCATION: SECRETED (POTENTIAL).
CC   -!- TISSUE SPECIFICITY: PANCREAS.
CC   -!- SIMILARITY: PARTIAL WITH OTHER LIPASES (PANCREATIC, GASTRIC,
CC       HEPATIC, LINGUAL, LIPOPROTEIN, BACTERIAL, ETC.).
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DR   EMBL; M93283; AAA59532.1; -.
DR   HSSP; P06857; 1RP1.
DR   MIM; 604422; -.
DR   INTERPRO; IPR000734; -.
DR   INTERPRO; IPR001024; -.
DR   INTERPRO; IPR002331; -.
DR   PFAM; PF01477; PLAT; 1.
DR   PFAM; PF00151; lipase; 1.
DR   PRINTS; PR00821; TAGLIPASE.
DR   PRINTS; PR00823; PANCLIPASE.
DR   PROSITE; PS00120; LIPASE_SER; 1.
KW   Hydrolase; Lipid degradation; Pancreas; Signal.
FT   SIGNAL        1     17       POTENTIAL.
FT   CHAIN        18    467       PANCREATIC LIPASE RELATED PROTEIN 1.
FT   ACT_SITE    171    171       CHARGE RELAY SYSTEM (BY SIMILARITY).
FT   ACT_SITE    194    194       CHARGE RELAY SYSTEM (BY SIMILARITY).
FT   ACT_SITE    281    281       CHARGE RELAY SYSTEM (BY SIMILARITY).
FT   DISULFID     21     27       BY SIMILARITY.
FT   DISULFID    109    120       BY SIMILARITY.
FT   DISULFID    255    279       BY SIMILARITY.
FT   DISULFID    303    314       BY SIMILARITY.
FT   DISULFID    317    322       BY SIMILARITY.
FT   DISULFID    451    467       BY SIMILARITY.
SQ   SEQUENCE   467 AA;  51847 MW;  2781EA1E22E39E78 CRC64;
     MLIFWTITLF LLGAAKGKEV CYEDLGCFSD TEPWGGTAIR PLKILPWSPE KIGTRFLLYT
     NENPNNFQIL LLSDPSTIEA SNFQMDRKTR FIIHGFIDKG DESWVTDMCK KLFEVEEVNC
     ICVDWKKGSQ ATYTQAANNV RVVGAQVAQM LDILLTEYSY PPSKVHLIGH SLGAHVAGEA
     GSKTPGLSRI TGLDPVEASF ESTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQQMG
     HLDFFPNGGE SMPGCKKNAL SQIVDLDGIW AGTRDFVACN HLRSYKYYLE SILNPDGFAA
     YPCTSYKSFE SDKCFPCPDQ GCPQMGHYAD KFAGRTSEEQ QKFFLNTGEA SNFARWRYGV
     SITLSGRTAT GQIKVALFGN KGNTHQYSIF RGILKPGSTH SYEFDAKLDV GTIEKVKFLW
     NNNVINPTLP KVGATKITVQ KGEEKTVYNF CSEDTVREDT LLTLTPC
//