ID   LIPR1_HUMAN    STANDARD;      PRT;   467 AA.
AC   P54315; Q68D83; Q68DR6; Q8TAU2; Q9BS82;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   05-SEP-2006, entry version 54.
DE   Pancreatic lipase-related protein 1 precursor (EC 3.1.1.3).
GN   Name=PNLIPRP1; Synonyms=PLRP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Pancreas;
RX   MEDLINE=92355622; PubMed=1379598;
RA   Giller T., Buchwald P., Blum-Kaelin D., Hunziker W.;
RT   "Two novel human pancreatic lipase related proteins, hPLRP1 and
RT   hPLRP2. Differences in colipase dependence and in lipase activity.";
RL   J. Biol. Chem. 267:16509-16516(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Liver;
RG   The German cDNA consortium;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   ASP-414.
RC   TISSUE=Pancreas;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a
CC       carboxylate.
CC   -!- SUBCELLULAR LOCATION: Secreted protein (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=P54315-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P54315-2; Sequence=VSP_014097, VSP_014100;
CC       Name=3;
CC         IsoId=P54315-3; Sequence=VSP_014098, VSP_014099;
CC   -!- TISSUE SPECIFICITY: Pancreas.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family.
CC   -!- SIMILARITY: Contains 1 PLAT domain.
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DR   EMBL; M93283; AAA59532.1; -; mRNA.
DR   EMBL; CR749299; CAH18154.1; -; mRNA.
DR   EMBL; CR749524; CAH18337.1; -; mRNA.
DR   EMBL; BC005233; AAH05233.1; -; mRNA.
DR   EMBL; BC025784; AAH25784.1; -; mRNA.
DR   PIR; A43357; A43357.
DR   UniGene; Hs.73923; -.
DR   HSSP; P06857; 1RP1.
DR   Ensembl; ENSG00000187021; Homo sapiens.
DR   H-InvDB; HIX0009236; -.
DR   HGNC; HGNC:9156; PNLIPRP1.
DR   MIM; 604422; gene.
DR   ArrayExpress; P54315; -.
DR   RZPD-ProtExp; IOH11964; -.
DR   RZPD-ProtExp; IOH7235; -.
DR   RZPD-ProtExp; M0524; -.
DR   GO; GO:0005576; C:extracellular region; TAS.
DR   GO; GO:0004806; F:triacylglycerol lipase activity; TAS.
DR   InterPro; IPR000734; Lipase.
DR   InterPro; IPR008262; Lipase_AS.
DR   InterPro; IPR008976; Lipase_LipOase.
DR   InterPro; IPR002331; Lipase_panc.
DR   InterPro; IPR001024; LipOase_LH2.
DR   InterPro; IPR000379; Ser_estrs.
DR   PANTHER; PTHR11610; Lipase; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PRINTS; PR00823; PANCLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SMART; SM00308; LH2; 1.
DR   PROSITE; PS00120; LIPASE_SER; 1.
DR   PROSITE; PS50095; PLAT; 1.
KW   Alternative splicing; Hydrolase; Lipid degradation; Polymorphism;
KW   Signal.
FT   SIGNAL        1     17       Potential.
FT   CHAIN        18    467       Pancreatic lipase-related protein 1.
FT                                /FTId=PRO_0000017790.
FT   DOMAIN      356    467       PLAT.
FT   ACT_SITE    171    171       Charge relay system (By similarity).
FT   ACT_SITE    194    194       Charge relay system (By similarity).
FT   ACT_SITE    281    281       Charge relay system (By similarity).
FT   DISULFID     21     27       By similarity.
FT   DISULFID    109    120       By similarity.
FT   DISULFID    255    279       By similarity.
FT   DISULFID    303    314       By similarity.
FT   DISULFID    317    322       By similarity.
FT   DISULFID    451    467       By similarity.
FT   VAR_SEQ     111    186       KLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQML
FT                                DILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPG -> VG
FT                                ASSDPCGQLRPTLLLTSLHHFMHSRNLYILGNFMQLKCFSS
FT                                QKLKCLSMFPHYICTLKQPHLLLEKYSYYLISG (in
FT                                isoform 2).
FT                                /FTId=VSP_014097.
FT   VAR_SEQ     111    117       KLFEVEE -> PGASPRA (in isoform 3).
FT                                /FTId=VSP_014098.
FT   VAR_SEQ     118    467       Missing (in isoform 3).
FT                                /FTId=VSP_014099.
FT   VAR_SEQ     187    467       Missing (in isoform 2).
FT                                /FTId=VSP_014100.
FT   VARIANT     271    271       A -> V (in dbSNP:2305205).
FT                                /FTId=VAR_022082.
FT   VARIANT     414    414       E -> D (in dbSNP:2305204).
FT                                /FTId=VAR_022659.
FT   VARIANT     461    461       L -> P (in dbSNP:1049125).
FT                                /FTId=VAR_014915.
SQ   SEQUENCE   467 AA;  51848 MW;  2781EA1E22E39E78 CRC64;
     MLIFWTITLF LLGAAKGKEV CYEDLGCFSD TEPWGGTAIR PLKILPWSPE KIGTRFLLYT
     NENPNNFQIL LLSDPSTIEA SNFQMDRKTR FIIHGFIDKG DESWVTDMCK KLFEVEEVNC
     ICVDWKKGSQ ATYTQAANNV RVVGAQVAQM LDILLTEYSY PPSKVHLIGH SLGAHVAGEA
     GSKTPGLSRI TGLDPVEASF ESTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQQMG
     HLDFFPNGGE SMPGCKKNAL SQIVDLDGIW AGTRDFVACN HLRSYKYYLE SILNPDGFAA
     YPCTSYKSFE SDKCFPCPDQ GCPQMGHYAD KFAGRTSEEQ QKFFLNTGEA SNFARWRYGV
     SITLSGRTAT GQIKVALFGN KGNTHQYSIF RGILKPGSTH SYEFDAKLDV GTIEKVKFLW
     NNNVINPTLP KVGATKITVQ KGEEKTVYNF CSEDTVREDT LLTLTPC
//