ID GBB1_RAT Reviewed; 340 AA. AC P54311; Q6Q8B1; Q9QWG8; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 4. DT 20-MAY-2008, entry version 65. DE Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 DE (Transducin beta chain 1). GN Name=Gnb1; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; TISSUE=Brain; RA Kuroda S., Tokunaga C., Konishi H., Kikkawa U.; RL Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; RX MEDLINE=97368252; PubMed=9221795; RA Wang X.B., Funada M., Imai Y., Revay R.S., Ujike H., Vandenbergh D.J., RA Uhl G.R.; RT "rGbeta1: a psychostimulant-regulated gene essential for establishing RT cocaine sensitization."; RL J. Neurosci. 17:5993-6000(1997). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Wistar; TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R.; RT "Cloning and characterization of the rat G-protein beta 1 subunit."; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PROTEIN SEQUENCE OF 58-78; 90-96; 138-150; 198-209; 284-301 AND RP 257-280, AND MASS SPECTROMETRY. RC STRAIN=Sprague-Dawley; TISSUE=Brain, and Hippocampus; RA Lubec G., Diao W., Afjehi-Sadat L., Chen W.-Q., Kang S.U.; RL Submitted (JUL-2007) to UniProtKB. RN [6] RP ACETYLATION AT SER-2, AND MASS SPECTROMETRY. RA Lubec G., Chen W.-Q.; RL Submitted (FEB-2007) to UniProtKB. CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are CC involved as a modulator or transducer in various transmembrane CC signaling systems, AND MASS SPECTROMETRY. The beta and gamma CC chains are required for the GTPase activity, for replacement of CC GDP by GTP, and for G protein-effector interaction. CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and CC gamma. CC -!- SIMILARITY: Belongs to the WD repeat G protein beta family. CC -!- SIMILARITY: Contains 7 WD repeats. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U34958; AAC72249.1; -; mRNA. DR EMBL; U88324; AAD00650.1; -; mRNA. DR EMBL; AY552805; AAS59143.1; -; mRNA. DR EMBL; BC078809; AAH78809.1; -; mRNA. DR RefSeq; NP_112249.2; -. DR UniGene; Rn.126047; -. DR UniGene; Rn.167040; -. DR HSSP; P04901; 1TBG. DR SMR; P54311; 1-339, 2-340. DR IntAct; P54311; -. DR Ensembl; ENSRNOG00000016638; Rattus norvegicus. DR GeneID; 24400; -. DR KEGG; rno:24400; -. DR RGD; 2718; Gnb1. DR GermOnline; ENSRNOG00000016638; Rattus norvegicus. DR InterPro; IPR001632; Gprotein_B. DR InterPro; IPR016346; Guanine_nucleotide-bd_bsu. DR InterPro; IPR015943; WD40/YVTN_repeat-like. DR InterPro; IPR001680; WD40_repeat. DR Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1. DR Pfam; PF00400; WD40; 7. DR PIRSF; PIRSF002394; GN-bd_beta; 1. DR PRINTS; PR00319; GPROTEINB. DR PRINTS; PR00320; GPROTEINBRPT. DR ProDom; PD000018; WD40; 5. DR SMART; SM00320; WD40; 7. DR PROSITE; PS00678; WD_REPEATS_1; 3. DR PROSITE; PS50082; WD_REPEATS_2; 6. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. PE 1: Evidence at protein level; KW Acetylation; Direct protein sequencing; Repeat; Transducer; WD repeat. FT INIT_MET 1 1 Removed. FT CHAIN 2 340 Guanine nucleotide-binding protein FT G(I)/G(S)/G(T) subunit beta-1. FT /FTId=PRO_0000127690. FT REPEAT 53 83 WD 1. FT REPEAT 95 125 WD 2. FT REPEAT 141 170 WD 3. FT REPEAT 182 212 WD 4. FT REPEAT 224 254 WD 5. FT REPEAT 268 298 WD 6. FT REPEAT 310 340 WD 7. FT MOD_RES 2 2 N-acetylserine. FT CONFLICT 208 208 A -> V (in Ref. 2; AAD00650). FT CONFLICT 277 277 S -> P (in Ref. 2; AAD00650). FT CONFLICT 287 287 A -> G (in Ref. 2; AAD00650). FT CONFLICT 301 301 K -> N (in Ref. 2; AAD00650). FT CONFLICT 307 307 V -> D (in Ref. 1; AAC72249). SQ SEQUENCE 340 AA; 37377 MW; 896CBD32D2686598 CRC64; MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN //