ID GBB1_RAT STANDARD; PRT; 339 AA. AC P54311; Q6Q8B1; Q9QWG8; DT 01-OCT-1996 (Rel. 34, Created) DT 13-SEP-2005 (Rel. 48, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1 DE (Transducin beta chain 1). GN Name=Gnb1; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; TISSUE=Brain; RA Kuroda S., Tokunaga C., Konishi H., Kikkawa U.; RL Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; RX MEDLINE=97368252; PubMed=9221795; RA Wang X.B., Funada M., Imai Y., Revay R.S., Ujike H., Vandenbergh D.J., RA Uhl G.R.; RT "rGbeta1: a psychostimulant-regulated gene essential for establishing RT cocaine sensitization."; RL J. Neurosci. 17:5993-6000(1997). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Wistar; TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R.; RT "Cloning and characterization of the rat G-protein beta 1 subunit."; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are CC involved as a modulator or transducer in various transmembrane CC signaling systems. The beta and gamma chains are required for the CC GTPase activity, for replacement of GDP by GTP, and for G protein- CC effector interaction. CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and CC gamma. CC -!- SIMILARITY: Contains 7 WD repeats. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U34958; AAC72249.1; -; mRNA. DR EMBL; U88324; AAD00650.1; -; mRNA. DR EMBL; AY552805; AAS59143.1; -; mRNA. DR EMBL; BC078809; AAH78809.1; -; mRNA. DR HSSP; P04901; 1TBG. DR SMR; P54311; 2-340. DR Ensembl; ENSRNOG00000016638; Rattus norvegicus. DR RGD; 2718; Gnb1. DR GO; GO:0005834; C:heterotrimeric G-protein complex; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR001632; Gprotein_B. DR InterPro; IPR001680; WD40. DR Pfam; PF00400; WD40; 7. DR PRINTS; PR00319; GPROTEINB. DR PRINTS; PR00320; GPROTEINBRPT. DR ProDom; PD000018; WD40; 5. DR SMART; SM00320; WD40; 7. DR PROSITE; PS00678; WD_REPEATS_1; 3. DR PROSITE; PS50082; WD_REPEATS_2; 6. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. KW Acetylation; Repeat; Transducer; WD repeat. FT INIT_MET 0 0 By similarity. FT REPEAT 52 82 WD 1. FT REPEAT 94 124 WD 2. FT REPEAT 140 169 WD 3. FT REPEAT 181 211 WD 4. FT REPEAT 223 253 WD 5. FT REPEAT 267 297 WD 6. FT REPEAT 309 339 WD 7. FT MOD_RES 1 1 N-acetylserine (By similarity). FT CONFLICT 207 207 A -> V (in Ref. 2). FT CONFLICT 276 276 S -> P (in Ref. 2). FT CONFLICT 286 286 A -> G (in Ref. 2). FT CONFLICT 300 300 K -> N (in Ref. 2). FT CONFLICT 306 306 V -> D (in Ref. 1). SQ SEQUENCE 339 AA; 37246 MW; E7BD59B83D1D4269 CRC64; SELDQLRQEA EQLKNQIRDA RKACADATLS QITNNIDPVG RIQMRTRRTL RGHLAKIYAM HWGTDSRLLV SASQDGKLII WDSYTTNKVH AIPLRSSWVM TCAYAPSGNY VACGGLDNIC SIYNLKTREG NVRVSRELAG HTGYLSCCRF LDDNQIVTSS GDTTCALWDI ETGQQTTTFT GHTGDVMSLS LAPDTRLFVS GACDASAKLW DVREGMCRQT FTGHESDINA ICFFPNGNAF ATGSDDATCR LFDLRADQEL MTYSHDNIIC GITSVSFSKS GRLLLAGYDD FNCNVWDALK ADRAGVLAGH DNRVSCLGVT DDGMAVATGS WDSFLKIWN //