ID GBB1_RAT STANDARD; PRT; 340 AA. AC P54311; Q6Q8B1; Q9QWG8; DT 01-OCT-1996 (Rel. 34, Created) DT 25-OCT-2004 (Rel. 45, Last sequence update) DT 10-MAY-2005 (Rel. 47, Last annotation update) DE Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1 DE (Transducin beta chain 1). GN Name=Gnb1; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sprague-Dawley; TISSUE=Brain; RA Kuroda S., Tokunaga C., Konishi H., Kikkawa U.; RL Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sprague-Dawley; RX MEDLINE=97368252; PubMed=9221795; RA Wang X.B., Funada M., Imai Y., Revay R.S., Ujike H., Vandenbergh D.J., RA Uhl G.R.; RT "rGbeta1: a psychostimulant-regulated gene essential for establishing RT cocaine sensitization."; RL J. Neurosci. 17:5993-6000(1997). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wistar; TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R.; RT "Cloning and characterization of the rat G-protein beta 1 subunit."; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are CC involved as a modulator or transducer in various transmembrane CC signaling systems. The beta and gamma chains are required for the CC GTPase activity, for replacement of GDP by GTP, and for G protein- CC effector interaction. CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and CC gamma. CC -!- SIMILARITY: Contains 7 WD repeats. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U34958; AAC72249.1; -; mRNA. DR EMBL; U88324; AAD00650.1; -; mRNA. DR EMBL; AY552805; AAS59143.1; -; mRNA. DR EMBL; BC078809; AAH78809.1; -; mRNA. DR HSSP; P04901; 1TBG. DR SMR; P54311; 1-340. DR Ensembl; ENSRNOG00000016638; Rattus norvegicus. DR RGD; 2718; Gnb1. DR GO; GO:0005834; C:heterotrimeric G-protein complex; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR001632; Gprotein_B. DR InterPro; IPR001680; WD40. DR InterPro; IPR011046; WD40_like. DR Pfam; PF00400; WD40; 7. DR PRINTS; PR00319; GPROTEINB. DR PRINTS; PR00320; GPROTEINBRPT. DR ProDom; PD000018; WD40; 5. DR SMART; SM00320; WD40; 7. DR PROSITE; PS00678; WD_REPEATS_1; 3. DR PROSITE; PS50082; WD_REPEATS_2; 6. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. KW Multigene family; Repeat; Transducer; WD repeat. FT REPEAT 53 83 WD 1. FT REPEAT 95 125 WD 2. FT REPEAT 141 170 WD 3. FT REPEAT 182 212 WD 4. FT REPEAT 224 254 WD 5. FT REPEAT 268 298 WD 6. FT REPEAT 310 340 WD 7. FT CONFLICT 208 208 A -> V (in Ref. 2). FT CONFLICT 277 277 S -> P (in Ref. 2). FT CONFLICT 287 287 A -> G (in Ref. 2). FT CONFLICT 301 301 K -> N (in Ref. 2). FT CONFLICT 307 307 V -> D (in Ref. 1). SQ SEQUENCE 340 AA; 37377 MW; 896CBD32D2686598 CRC64; MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN //